The genetic epidemiology of hereditary breast cancer / Douglas F. Easton, Antonis C. Antoniou, and Deborah Thompson -- Risk prediction in breast cancer / Lisa Walker and Rosalind Eeles -- Bioethics of genetic testing for hereditary breast cancer / Beth N. Peshkin and Wylie Burke -- Cancer risks in BRCA1 and BRCA2 mutation carriers / Kenneth Offit and Peter Thom -- PTEN and Cowden syndrome / Kevin M. Zbuk, Jennifer Stein, and Charis Eng -- Li-Fraumeni syndrome / Louise C. Strong -- Rare causes of inherited breast cancer susceptibility / Katherine L. Nathanson -- Low-penetrance genes in breast cancer / Paul D.P. Pharoah -- Biology of BRCA1- and BRCA2-associated carcinogenesis / Jenny Llamas and Lawrence C. Brody -- Genetic testing and counseling issues / Jill Stopfer, Vickie Venne, and Katherine Schneider -- Molecular diagnostics : methods and limitations / Sean V. Tavtigian and Florence LeCalvez-Kelm -- Breast cancer risk modifiers / Roger Milne and Georgia Chenevix-Trench -- BRCA1 and BRCA2 in underserved and special populations / Bifeng Zhang and Olufunmilayo I. Olopade -- Psychological and behavioral impact of BRCA1/2 genetic testing / Kristi Graves and Marc D. Schwartz -- Breast cancer screening and prevention options in BRCA1 and BRCA2 mutation carriers / Karen Lisa Smith and Claudine Isaacs -- Ovarian cancer screening and prevention options : ovarian cancer screening and its limitations. Who should be screened? / Karen H. Lu and Steven J. Skates -- Management of BRCA-negative hereditary breast cancer families / Noah D. Kauff -- Pathology of breast tumors in hereditary breast cancer / William D. Foulkes and Lars A. Akslen -- Pathology of ovarian tumors in mutation carriers / Frédérique Penault-Llorca and Sunil R. Lakhani -- Local treatment issues in women with hereditary breast cancer / Merav A. Ben-David and Lori J. Pierce -- Systemic therapy for BRCA-associated breast cancer / Mark Robson.