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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005092naa a22010453a 4500
00122096846
003SE-LIBR
00520171209153203.0
007cr||||||||||||
008171209s2012 sw |||| o |||| ||eng c
024a http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-797952 uri
024a urn:nbn:se:su:diva-797952 urn
024a 10.1002/pro.20712 doi
040 a S
041a eng
042 9 EPLK
100a Liberles, David A.4 aut
2451 0a The interface of protein structure, protein biophysics, and molecular evolutionh [Elektronisk resurs]
260 c 2012
500 a <p>AuthorCount:33;</p>
500 a Published
506a gratis
520 a The interface of protein structural biology, protein biophysics, molecular evolution, and molecular population genetics forms the foundations for a mechanistic understanding of many aspects of protein biochemistry. Current efforts in interdisciplinary protein modeling are in their infancy and the state-of-the art of such models is described. Beyond the relationship between amino acid substitution and static protein structure, protein function, and corresponding organismal fitness, other considerations are also discussed. More complex mutational processes such as insertion and deletion and domain rearrangements and even circular permutations should be evaluated. The role of intrinsically disordered proteins is still controversial, but may be increasingly important to consider. Protein geometry and protein dynamics as a deviation from static considerations of protein structure are also important. Protein expression level is known to be a major determinant of evolutionary rate and several considerations including selection at the mRNA level and the role of interaction specificity are discussed. Lastly, the relationship between modeling and needed high-throughput experimental data as well as experimental examination of protein evolution using ancestral sequence resurrection and in vitro biochemistry are presented, towards an aim of ultimately generating better models for biological inference and prediction.
650 7a Natural Sciences2 hsv
650 7a Biological Sciences2 hsv
650 7a Biochemistry and Molecular Biology2 hsv
650 7a Naturvetenskap2 hsv0 264446
650 7a Biologiska vetenskaper2 hsv
650 7a Biokemi och molekylärbiologi2 hsv
653 0a evolutionary modeling
653 0a domain evolution
653 0a sequence-structure-function relationships
653 0a protein dynamics
653 0a protein thermodynamics
653 0a gene duplication
653 0a protein expression
653 0a ancestral sequence reconstruction
700a Teichmann, Sarah A.4 aut
700a Bahar, Ivet4 aut
700a Bastolla, Ugo4 aut
700a Bloom, Jesse4 aut
700a Bornberg-Bauer, Erich4 aut
700a Colwell, Lucy J.4 aut
700a de Koning, A. P. Jason4 aut
700a Dokholyan, Nikolay V.4 aut
700a Echave, Julian4 aut
700a Elofsson, Arne4 aut
700a Gerloff, Dietlind L.4 aut
700a Goldstein, Richard A.4 aut
700a Grahnen, Johan A.4 aut
700a Holder, Mark T.4 aut
700a Lakner, Clemens4 aut
700a Lartillot, Nicholas4 aut
700a Lovell, Simon C.4 aut
700a Naylor, Gavin4 aut
700a Perica, Tina4 aut
700a Pollock, David D.4 aut
700a Pupko, Tal4 aut
700a Regan, Lynne4 aut
700a Roger, Andrew4 aut
700a Rubinstein, Nimrod4 aut
700a Shakhnovich, Eugene4 aut
700a Sjoelander, Kimmen4 aut
700a Sunyaev, Shamil4 aut
700a Teufel, Ashley I.4 aut
700a Thorne, Jeffrey L.4 aut
700a Thornton, Joseph W.4 aut
700a Weinreich, Daniel M.4 aut
700a Whelan, Simon4 aut
7101 2a Stockholms universitetb Naturvetenskapliga fakulteten4 pbl
7721 8i channel recordw 19642870
7730 8i Värdpublikationt Protein Scienceg 21:6, 769-785x 0961-8368
8564 0u http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-79795
8564 0u http://dx.doi.org/10.1002/pro.2071
8564 0u http://su.diva-portal.org/smash/get/diva2:551573/FULLTEXT02
950 k6 650a Atomerw hu Naturvetenskap
950 k6 650a Experimentw hu Naturvetenskap
950 k6 650a Fysikw hu Naturvetenskap
950 k6 650a Kemiw hu Naturvetenskap
950 k6 650a Kloningw hu Naturvetenskap
950 k6 650a Laboratorierw hu Naturvetenskap
950 k6 650a Marinbiologiw hu Naturvetenskap
950 k6 650a Matematikw hu Naturvetenskap
950 k6 650a Medicinska experimentw hu Naturvetenskap
950 k6 650a Tyngdlagenw hu Naturvetenskap
950 k6 650a Utvecklingsläraw hu Naturvetenskap
841 5 APISa x ab 171210||0000|||||001||||||000000e 1
0245 APISa urn:nbn:se:su:diva-797952 urn
852 5 APISb APIS
8564 05 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-79795

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