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Sökning: onr:"swepub:oai:DiVA.org:hh-41454" > Myocardial Blood Fl...

Myocardial Blood Flow and Metabolic Rate of Oxygen Measurement in the Right and Left Ventricles at Rest and During Exercise Using 15O-Labeled Compounds and PET

Kudomi, Nobuyuki (författare)
Turku PET Centre, University of Turku, Turku, Finland & Department of Medical Physics, Faculty of Medicine, Kagawa University, Kagawa, Japan
Kalliokoski, Kari K. (författare)
Turku PET Centre, University of Turku, Turku, Finland
Oikonen, Vesa J. (författare)
Turku PET Centre, University of Turku, Turku, Finland
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Han, Chunlei (författare)
Turku PET Centre, University of Turku, Turku, Finland
Kemppainen, Jukka (författare)
Turku PET Centre, University of Turku, Turku, Finland & Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland
Sipila, Hannu T. (författare)
Turku PET Centre, University of Turku, Turku, Finland
Knuuti, Juhani (författare)
Turku PET Centre, University of Turku, Turku, Finland & Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland
Heinonen, Ilkka, 1982- (författare)
Högskolan i Halmstad,Rydberglaboratoriet för tillämpad naturvetenskap (RLAS),Turku PET Centre, University of Turku, Turku, Finland & Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland
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 (creator_code:org_t)
Lausanne : Frontiers Media S.A. 2019
2019
Engelska.
Ingår i: ; 10
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Aims: Simultaneous measurement of right (RV) and left ventricle (LV) myocardial blood flow (MBF), oxygen extraction fraction (OEF), and oxygen consumption (MVO2) non-invasively in humans would provide new possibilities to understand cardiac physiology and different patho-physiological states. Methods: We developed and tested an optimized novel method to measure MBF, OEF, and MVO2 simultaneously both in the RV and LV free wall (FW) using positron emission tomography in healthy young men at rest and during supine bicycle exercise. Results: Resting MBF was not significantly different between the three myocardial regions. Exercise increased MBF in the LVFW and septum, but MBF was lower in the RV compared to septum and LVFW during exercise. Resting OEF was similar between the three different myocardial regions (similar to 70%) and increased in response to exercise similarly in all regions. MVO2 increased approximately two to three times from rest to exercise in all myocardial regions, but was significantly lower in the RV during exercise as compared to septum LVFW. Conclusion: MBF, OEF, and MVO2 can be assessed simultaneously in the RV and LV myocardia at rest and during exercise. Although there are no major differences in the MBF and OEF between LV and RV myocardial regions in the resting myocardium, MVO2 per gram of myocardium appears to be lower the RV in the exercising healthy human heart due to lower mean blood flow. The presented method may provide valuable insights for the assessment of MBF, OEF and MVO2 in hearts in different pathophysiological states.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Nyckelord

positron emission tomography
myocardial blood flow
myocardial oxygen metabolism
right ventricle
left ventricle

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