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Expression of NF-kappa B p65 phosphorylated at serine-536 in rectal cancer with or without preoperative radiotherapy

Lewander, Andreas (författare)
Department of Oncology, Institute of Clinical and Experimental Medicine, University of Linköping, SE-581 85 Linköping, Sweden
Gao, Jinfang (författare)
Department of Oncology, Institute of Clinical and Experimental Medicine, University of Linköping, SE-581 85 Linköping, Sweden
Adell, Gunnar (författare)
Department of Oncology, Karolinska University Hospital, Stockholm, Sweden
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Zhang, Hong (författare)
Högskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi
Sun, Xiao-Feng (författare)
Department of Oncology, Institute of Clinical and Experimental Medicine, University of Linköping, SE-581 85 Linköping, Sweden
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 (creator_code:org_t)
Walter de Gruyter, 2011
2011
Engelska.
Ingår i: Radiology and Oncology. - : Walter de Gruyter. - 1318-2099 .- 1581-3207. ; 45:4, s. 279-284
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background. In the present study, we investigated NF-kappa B p65 phosphorylated at Serine-536 (phosphor-Ser536-p65) in rectal cancer and its relationship to preoperative radiotherapy (RT), clinicopathological variables and biological factors. Patients and methods. Expression of phosphor-Ser536-p65 was examined by using immunohistochemistry in 141 primary rectal cancers, 149 normal mucosa specimens and 48 metastases in the lymph nodes, from rectal cancer patients who participated in a Swedish clinical trial of preoperative RT. Results. The expression of phosphor-Ser536-p65 in the cytoplasm increased from normal mucosa to primary tumour (p<0.0001, for both the group that did and the group that did not received RT). The expression did not further increase from primary tumour to metastasis in either group (p>0.05). Expression of phosphor-Ser536-p65 was positively related to, or tended to be related to, the expression of tumour endothelium marker 1 (TEM1, p=0.02), FXYD-3 (p=0.001), phosphatase of regenerating liver (PRL, p=0.02), p73 (p=0.048) and meningioma associated protein (MAC30, p=0.05) in the group that received RT but there were no such relationships in the group that did not received RT (p>0.05). The expression of phosphor-Ser536-p65 was not related to clinicopathological factors including survival (p>0.05). Conclusions. The increased expression of phosphor-Ser536-p65 may be involved in rectal cancer development. After RT, phosphor-Ser536-p65 seems to be positively related to the biological factors, which associated with more malignant features of tumours. However, phosphor-Ser536-p65 was not directly related to the response of RT based on recurrence and survival.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

NF-kappa B
serine-536
radiotherapy
rectal cancer
immunohistochemistry
recurrence
prognosis
Medical sciences
Medicin

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Lewander, Andrea ...
Gao, Jinfang
Adell, Gunnar
Zhang, Hong
Sun, Xiao-Feng
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MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
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Högskolan i Skövde

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