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5-HTTLPR/rs25531 polymorphism and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus

Kruschwitz, J. D. (författare)
Charité, Berlin
Walter, M. (författare)
University Hospital of Magdeburg
Varikuti, D. (författare)
University Hospital of Magdeburg
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Jensen, Jimmy (författare)
Högskolan Kristianstad,Avdelningen för Humanvetenskap
Plichta, M. M. (författare)
University of Heidelberg
Haddad, L. (författare)
University of Heidelberg
Grimm, O. (författare)
University of Heidelberg
Mohnke, S. (författare)
Charité, Berlin
Pöhland, L. (författare)
Charité, Berlin
Schott, B. (författare)
Charité, Berlin
Wold, A. (författare)
Charité, Berlin
Mühleisen, T. W. (författare)
University of Bonn
Heinz, A. (författare)
Charité, Berlin
Erk, S. (författare)
Charité, Berlin
Romanczuk-Seiferth, N. (författare)
Charité, Berlin
Witt, S. H. (författare)
University of Heidelberg
Nöthen, M. M. (författare)
University of Bonn
Rietschel, M. (författare)
University of Heidelberg
Meyer-Lindenberg, A. (författare)
University of Heidelberg
Walter, H. (författare)
Charité, Berlin
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 (creator_code:org_t)
2015
2015
Engelska.
Ingår i: Brain Structure and Function. - 1863-2653 .- 1863-2661. ; 220:4, s. 2373-2385
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The s/s-genotype of the 5-HTTLPR polymorphism and the personality trait of neuroticism have both been associated with experiences of negative affect, anxiety and mood disorders, as well as an emotional processing bias towards negative facial emotions. On a neural level, this bias can be characterized by altered amygdala and fusiform gyrus (FFG) activity during perception of negative facial expressions. Using resting-state functional magnetic resonance imaging in a multi-center-sample of 178 healthy subjects of European descent, this study investigated the association of 5-HTTLPR (short s- and long l-allele) including the genotype of the single nucleotide polymorphism (SNP) rs25531 (A/G) within this region polymorphism, and trait neuroticism on resting-state functional connectivity (rs-FC) between amygdala and the FFG. Moreover, we aimed to identify additional brain regions with associations of 5-HTTLPR/rs25531 (combined according to its expression; low: s/s; high: lA/lA; intermediate: s/lA, s/lG, lG/lG, lA/lG) and trait neuroticism to amygdala rs-FC. Separate analyses for 5-HTTLPR/rs25531 and neuroticism (controlling for age, gender, handedness, and research site) revealed that s/s-homozygotes and individuals high in neuroticism obtained altered amygdala rs-FC in the right occipital face area, which is considered to be a "core component" of the face processing system. Importantly, effects of neuroticism were replicated across three independent research sites. Additionally, associations of 5-HTTLPR/rs25531 genotype and amygdala rs-FC were observed in the anterior and posterior cingulate cortex, whereas neuroticism was not related to rs-FC in these areas. The presented data implies that 5-HTTLPR/rs25531 variants and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus and suggests that variants of 5-HTTLPR/rs25531 genotype and different levels of neuroticism may partly account for altered processing of negative facial emotions.

Ämnesord

SOCIAL SCIENCES  -- Psychology (hsv//eng)
SAMHÄLLSVETENSKAP  -- Psykologi (hsv//swe)

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