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Prenatal paracetamol exposure and child neurodevelopment : A review

Bauer, A. Z., (författare)
University of Massachusetts, 1 University Avenue, Lowell, MA, 01854, USA
Kriebel, D., (författare)
University of Massachusetts, 1 University Avenue, Lowell, MA, 01854, USA
Herbert, M. R., (författare)
Harvard Medical School, Charlestown USA
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Bornehag, Carl-Gustaf, 1957- (författare)
Karlstads universitet, Institutionen för hälsovetenskaper (from 2013)
Swan, S. H., (författare)
Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA
visa färre...
Karlstads universitet Fakulteten för hälsa, natur- och teknikvetenskap (from 2013). Institutionen för hälsovetenskaper (from 2013). (creator_code:org_t)
2018
Engelska.
Ingår i: Hormones and Behavior. - Academic Press Inc.. - 0018-506X.
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: The non-prescription medication paracetamol (acetaminophen, APAP) is currently recommended as a safe pain and fever treatment during pregnancy. However, recent studies suggest a possible association between APAP use in pregnancy and offspring neurodevelopment. Objectives: To conduct a review of publications reporting associations between prenatal APAP use and offspring neurodevelopmental outcomes. Methods: Relevant sources were identified through a key word search of multiple databases (Medline, CINAHL, OVID and TOXNET) in September 2016. All English language observational studies of pregnancy APAP and three classes of neurodevelopmental outcomes (autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and intelligence quotient (IQ)) were included. One reviewer (AZB) independently screened all titles and abstracts, extracted and analyzed the data. Results: 64 studies were retrieved and 55 were ineligible. Nine prospective cohort studies fulfilled all inclusion criteria. Data pooling was not appropriate due to heterogeneity in outcomes. All included studies suggested an association between prenatal APAP exposure and the neurodevelopmental outcomes; ADHD, ASD, or lower IQ. Longer duration of APAP use was associated with increased risk. Associations were strongest for hyperactivity and attention-related outcomes. Little modification of associations by indication for use was reported. Conclusions: Together, these nine studies suggest an increased risk of adverse neurodevelopmental outcomes following prenatal APAP exposure. Further studies are urgently needed with; precise indication of use and exposure assessment of use both in utero and in early life. Given the current findings, pregnant women should be cautioned against indiscriminate use of APAP. These results have substantial public health implications.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Acetaminophen
ADHD
APAP
ASD
Attention deficit hyperactivity disorder
Autism
Autism spectrum disorder
Behavior
Hyperactivity
Neurodevelopment
Paracetamol
Public Health Science
Folkhälsovetenskap

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Bauer, A. Z.
Kriebel, D.
Herbert, M. R.
Bornehag, Carl-G ...
Swan, S. H.
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MEDICIN OCH HÄLSOVETENSKAP
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Karlstads universitet

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