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  • Boman, K. (författare)

Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer

  • Artikel/kapitelEngelska2013

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-136897
  • 10.1038/bjc.2013.215doi
  • 23652315pmid
  • 2-s2.0-84884185522scopus
  • urn:nbn:se:kth:diva-136897urn

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Published
  • 10
  • <p>QC 20131213</p>
  • <p>Background: Membranous expression of the anti-adhesive glycoprotein podocalyxin-like (PODXL) has previously been found to correlate with poor prognosis in several major cancer forms. Here we examined the prognostic impact of PODXL expression in urothelial bladder cancer. Methods: Immunohistochemical PODXL expression was examined in tissue microarrays with tumours from two independent cohorts of patients with urothelial bladder cancer: n = 100 (Cohort I) and n = 343 (Cohort II). The impact of PODXL expression on disease-specific survival (DSS; Cohort II), 5-year overall survival (OS; both cohorts) and 2-year progression-free survival (PFS; Cohort II) was assessed. Results: Membranous PODXL expression was significantly associated with more advanced tumour (T) stage and high-grade tumours in both cohorts, and a significantly reduced 5-year OS (unadjusted HR = 2.25 in Cohort I and 3.10 in Cohort II, adjusted HR = 2.05 in Cohort I and 2.18 in Cohort II) and DSS (unadjusted HR = 4.36, adjusted HR = 2.70). In patients with Ta and T1 tumours, membranous PODXL expression was an independent predictor of a reduced 2-year PFS (unadjusted HR = 6.19, adjusted HR = 4.60) and DSS (unadjusted HR = 8.34, adjusted HR = 7.16). Conclusion: Membranous PODXL expression is an independent risk factor for progressive disease and death in patients with urothelial bladder cancer.</p>

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Larsson, A. H.(SwePub:) (författare)
  • Segersten, U.(SwePub:) (författare)
  • Kuteeva, E.(SwePub:) (författare)
  • Johannesson, H.(SwePub:) (författare)
  • Nodin, B.(SwePub:) (författare)
  • Eberhard, J.(SwePub:) (författare)
  • Uhlén, Mathias,KTH, Proteomik och nanobioteknologi, KTH, Science for Life Laboratory, SciLifeLab(SwePub:kth) (författare)
  • Malmström, P-U(SwePub:) (författare)
  • Jirström, K.(SwePub:) (författare)

Sammanhörande titlar

  • Ingår i:British Journal of Cancer0007-09201532-1827108:11, s. 2321-2328

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