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Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome

Lovric, Alen, (författare)
KTH, Science for Life Laboratory, SciLifeLab
Graner, Marit, (författare)
Univ Helsinki, Heart & Lung Ctr, Div Cardiol, Cent Hosp, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
Bjornson, Elias, (författare)
Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden.;Univ Gothenburg, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden.
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Arif, Muhammad, (författare)
KTH, Science for Life Laboratory, SciLifeLab
Benfeitas, Rui, (författare)
KTH, Science for Life Laboratory, SciLifeLab
Nyman, Kristofer, (författare)
Univ Helsinki, Helsinki, Finland.;Univ Helsinki, HUS Med Imaging Ctr, Dept Radiol, Cent Hosp, Helsinki, Finland.
Stahlman, Marcus, (författare)
Univ Gothenburg, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden.
Pentikainen, Markku O., (författare)
Univ Helsinki, Heart & Lung Ctr, Div Cardiol, Cent Hosp, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
Lundborn, Jesper, (författare)
Univ Helsinki, Helsinki, Finland.;Univ Helsinki, HUS Med Imaging Ctr, Dept Radiol, Cent Hosp, Helsinki, Finland.
Hakkarainen, Antti, (författare)
Univ Helsinki, Helsinki, Finland.;Univ Helsinki, HUS Med Imaging Ctr, Dept Radiol, Cent Hosp, Helsinki, Finland.
Siren, Reijo, (författare)
Univ Helsinki, Helsinki, Finland.;Hlth Care Ctr City Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
Nieminen, Markku S., (författare)
Univ Helsinki, Heart & Lung Ctr, Div Cardiol, Cent Hosp, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
Lundborns, Nina, (författare)
Univ Helsinki, Helsinki, Finland.;Univ Helsinki, HUS Med Imaging Ctr, Dept Radiol, Cent Hosp, Helsinki, Finland.
Lauermas, Kirsi, (författare)
Univ Helsinki, Helsinki, Finland.;Univ Helsinki, HUS Med Imaging Ctr, Dept Radiol, Cent Hosp, Helsinki, Finland.
Taskinen, Marja-Riitta, (författare)
Univ Helsinki, Heart & Lung Ctr, Div Cardiol, Cent Hosp, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
Mardinoglu, Adil, (författare)
KTH, Science for Life Laboratory, SciLifeLab
Boren, Jan, (författare)
Univ Gothenburg, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden.
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2018
Engelska.
Ingår i: Scientific Reports. - Nature Publishing Group. - 2045-2322 .- 2045-2322. ; 8
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p>Non-alcoholic fatty liver disease (NAFLD) is recognized as a liver manifestation of metabolic syndrome, accompanied with excessive fat accumulation in the liver and other vital organs. Ectopic fat accumulation was previously associated with negative effects at the systemic and local level in the human body. Thus, we aimed to identify and assess the predictive capability of novel potential metabolic biomarkers for ectopic fat depots in non-diabetic men with NAFLD, using the inflammation-associated proteome, lipidome and metabolome. Myocardial and hepatic triglycerides were measured with magnetic spectroscopy while function of left ventricle, pericardial and epicardial fat, subcutaneous and visceral adipose tissue were measured with magnetic resonance imaging. Measured ectopic fat depots were profiled and predicted using a Random Forest algorithm, and by estimating the Area Under the Receiver Operating Characteristic curves. We have identified distinct metabolic signatures of fat depots in the liver (TAG50:1, glutamate, diSM18:0 and CE20:3), pericardium (N-palmitoyl-sphinganine, HGF, diSM18:0, glutamate, and TNFSF14), epicardium (sphingomyelin, CE20:3, PC38:3 and TNFSF14), and myocardium (CE20:3, LAPTGF-beta 1, glutamate and glucose). Our analyses highlighted non-invasive biomarkers that accurately predict ectopic fat depots, and reflect their distinct metabolic signatures in subjects with NAFLD.</p>

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MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

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