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Uniform mesoporous ...
Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient, nontoxic MRI T 2 contrast agent with tunable proton relaxivities
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- Ye, Fei (författare)
- KTH,Funktionella material, FNM,KTH Royal Institute of Technology, Sweden
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- Laurent, Sophie (författare)
- University of Mons, Belgium
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- Fornara, Andrea (författare)
- KTH,RISE,YKI – Ytkemiska institutet,Funktionella material, FNM
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- Astolfi, Laura (författare)
- University of Padua, Italy
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- Qin, Jian (författare)
- KTH,Funktionella material, FNM,KTH Royal Institute of Technology, Sweden; ABB, Sweden
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- Roch, Alain (författare)
- University of Mons, Belgium
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- Martini, Alessandro (författare)
- University of Padua, Italy
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- Toprak, Muhammet (författare)
- KTH,Funktionella material, FNM,KTH Royal Institute of Technology, Sweden
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- Müller, Robert N. (författare)
- University of Mons, Belgium
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- Muhammed, Mamoun (författare)
- KTH,Funktionella material, FNM,KTH Royal Institute of Technology, Sweden
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(creator_code:org_t)
- 2012-07-17
- 2012
- Engelska.
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Ingår i: Contrast Media & Molecular Imaging. - : Wiley. - 1555-4309 .- 1555-4317. ; 7:5, s. 460-468
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Monodisperse mesoporous silica (mSiO 2) coated superparamagnetic iron oxide (Fe 3O 4@mSiO 2) nanoparticles (NPs) have been developed as a potential magnetic resonance imaging (MRI) T 2 contrast agent. To evaluate the effect of surface coating on MRI contrast efficiency, we examined the proton relaxivities of Fe 3O 4@mSiO 2 NPs with different coating thicknesses. It was found that the mSiO 2 coating has a significant impact on the efficiency of Fe 3O 4 NPs for MRI contrast enhancement. The efficiency increases with the thickness of mSiO 2 coating and is much higher than that of the commercial contrast agents. Nuclear magnetic resonance (NMR) relaxometry of Fe 3O 4@mSiO 2 further revealed that mSiO 2 coating is partially permeable to water molecules and therefore induces the decrease of longitudinal relaxivity, r 1. Biocompatibility evaluation of various sized (ca. 35-95 nm) Fe 3O 4@mSiO 2 NPs was tested on OC-k3 cells and the result showed that these particles have no negative impact on cell viability. The enhanced MRI efficiency of Fe 3O 4@mSiO 2 highlights these core-shell particles as highly efficient T 2 contrast agents with high biocompatibility.
Nyckelord
- Biocompatibility
- Coating thickness
- Contrast agent
- Iron oxide
- Mesoporous silica
- MRI
- Superparamagnetic
- Tunable relaxivity Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient
- nontoxic MRI T 2 contrast agent with tunable proton relaxivities
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Ye, Fei
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Laurent, Sophie
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Fornara, Andrea
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Astolfi, Laura
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Qin, Jian
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Roch, Alain
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visa fler...
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Martini, Alessan ...
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Toprak, Muhammet
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Müller, Robert N ...
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Muhammed, Mamoun
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- Artiklar i publikationen
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Contrast Media & ...
- Av lärosätet
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RISE
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Kungliga Tekniska Högskolan