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Sökning: onr:"swepub:oai:DiVA.org:liu-101425" > Familial aggregatio...

Familial aggregation of tinnitus : a European multicentre study

Hendrickx, Jan-Jaap (författare)
University Hospital of Antwerp, Belgium,Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium; Department of Otorhinolaryngology, University of Oulu, Oulu, Finland; Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands; Department of Otolaryngology, University Hospital Antwerp, Wilrijkstraat 10, Antwerp, Belgium
Huyghe, Jeroen (författare)
University of Antwerp, Belgium
Demeester, Kelly (författare)
University Hospital of Antwerp, Belgium,Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
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Topsakal, Velat (författare)
University Hospital of Antwerp, Belgium
Van Eyken, Els (författare)
University of Antwerp, Belgium,Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Fransen, Erik (författare)
University of Antwerp, Belgium,Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Mäki-Torkko, Elina (författare)
Örebro universitet,Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Öronkliniken US,University of Oulu, Finland,Institutionen för medicinska vetenskaper,Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
Hannula, Samuli (författare)
University of Oulu, Finland,Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
Jensen, Mona (författare)
Bispebjerg Hospital, Copenhagen, Denmark,Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark
Tropitzsch, A. (författare)
Bonaconsa, Amanda (författare)
University Hospital Padova, Italy,Department of Oto-surgery, University Hospital Padova, Padova, Italy
Mazzoli, Manuela (författare)
University Hospital Padova, Italy,Department of Oto-surgery, University Hospital Padova, Padova, Italy
Espesp, Angeles (författare)
University Hospital of Wales, Cardiff, UK
Verbruggen, Katia (författare)
University Hospital of Gent, Belgium,Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
Huyghe, Joke (författare)
University Hospital of Gent, Belgium,Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
Huygen, Patrick (författare)
Radboud University Nijmegen Medical Centre, the Netherlands
Kremer, Hannie (författare)
Radboud University Nijmegen Medical Centre, the Netherlands
Kunst, Sylvia (författare)
Radboud University Nijmegen Medical Centre, the Netherlands
Manninen, Minna (författare)
University of Tampere, Finland,Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
Diaz-Lacava, AN (författare)
University of Bonn, Germany
Steffens, Michael (författare)
University of Bonn, Germany,Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
Parving, Agnete (författare)
Bispebjerg Hospital, Copenhagen, Denmark,Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark
Pyykkö, Ilmari (författare)
University of Tampere, Finland
Dhooge, Ingeborg (författare)
University Hospital of Gent, Belgium
Stephens, Dafydd (författare)
University Hospital of Wales, Cardiff, UK,Welsh Hearing Institute, Cardiff University, Cardiff, United Kingdom
Orzan, Eva (författare)
University of Padova, Italy,Department of Oto-surgery, University Hospital Padova, Padova, Italy
Pfister, Markus (författare)
University of Tuebingen, Germany
Bille, Mikael (författare)
Bispebjerg Hospital, Copenhagen, Denmark
Sorri, Martti (författare)
University of Oulu, Finland
Cremers, Cor (författare)
Radboud University Nijmegen Medical Centre, the Netherlands
Van Laer, Lut (författare)
University of Antwerp, Belgium,Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Van Camp, Guy (författare)
University of Antwerp, Belgium
Wienker, Thomas (författare)
University of Bonn, Germany
Van de Heyning, Paul (författare)
University Hospital of Antwerp, Belgium,Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
Van Camp, Guy V. (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Kunst, S J (författare)
Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands
Kremer, Hannie Ph. (författare)
Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands
Topsakal, Vedat V. (författare)
Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
Huyghe, Jeroen R. (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Tropitzsch, Anke S. (författare)
Department of Otorhinolaryngology, University of Tübingen, Tübingen, Germany
Sorri, Martti J. (författare)
Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
Pfister, Markus H.F. (författare)
Department of Otorhinolaryngology, University of Tübingen, Tübingen, Germany
Cremers, Cor Wrj R.J. (författare)
Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands
Huygen, Patrick L.M. (författare)
Department of Otorhinolaryngology, UMC Nijmegen, Nijmegen, Netherlands
Espeso, Angeles (författare)
Welsh Hearing Institute, Cardiff University, Cardiff, United Kingdom
Dhooge, Ingeborg Johanna Maria (författare)
Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
Diaz-Lacava, Amalia N. (författare)
Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
Wienker, Thomas F. (författare)
Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
Bille, Michael (författare)
Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark
Pyykkö, Ilmari V. (författare)
Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
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 (creator_code:org_t)
Louvain, Belgium : Societe Royale Belge d'Oto - Rhino - Laryngologie et de Chirurgie Cervico - Faciale, 2007
2007
Engelska.
Ingår i: B-ENT. - Louvain, Belgium : Societe Royale Belge d'Oto - Rhino - Laryngologie et de Chirurgie Cervico - Faciale. - 0001-6497. ; 3:Suppl 7, s. 51-60
  • Tidskriftsartikel (övrigt vetenskapligt)
Abstract Ämnesord
Stäng  
  • INTRODUCTION AND AIM:Tinnitus is a common condition affecting approximately 20% of the older population. There is increasing evidence that changes in the central auditory system following cochlear malfunctioning are responsible for tinnitus. To date, few investigators have studied the influence of genetic factors on tinnitus. The present report investigates the presence of a familial effect in tinnitus subjects.METHODS:In a European multicentre study, 198 families were recruited in seven European countries. Each family had at least 3 siblings. Subjects were screened for causes of hearing loss other than presbyacusis by clinical examination and a questionnaire. The presence of tinnitus was evaluated with the question "Nowadays, do you ever get noises in your head or ear (tinnitus) which usually last longer than five minutes". Familial aggregation was tested using three methods: a mixed model approach, calculating familial correlations, and estimating the risk of a subject having tinnitus if the disorder is present in another family member.RESULTS:All methods demonstrated a significant familial effect for tinnitus. The effect persisted after correction for the effect of other risk factors such as hearing loss, gender and age. The size of the familial effect is smaller than that for age-related hearing impairment, with a familial correlation of 0.15.CONCLUSION:The presence of a familial effect for tinnitus opens the door to specific studies that can determine whether this effect is due to a shared familial environment or the involvement of genetic factors. Subsequent association studies may result in the identification of the factors responsible. In addition, more emphasis should be placed on the effect of role models in the treatment of tinnitus. 

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oto-rino-laryngologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

etiology
presbyacousis
familial aggregation
tinnitus
heredity

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