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Sökning: onr:"swepub:oai:DiVA.org:liu-101453" > Familial Aggregatio...

Familial Aggregation of Pure Tone Hearing Thresholds in an Aging European Population

Hendrickx, Jan-Jaap (författare)
University Hospital of Antwerp and University of Antwerp, Belgium,University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium; Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUa Statistics Center, University of Antwerp, Antwerp, Belgium; Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
Huyghe, Jeroen (författare)
University of Antwerp, Belgium
Topsakal, Vedat (författare)
University Hospital of Antwerp, Belgium,University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
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Demeester, Kelly (författare)
University Hospital of Antwerp, Belgium,University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
Wienker, Thomas (författare)
University of Bonn, Germany
Van Laer, Lut (författare)
University of Antwerp, Belgium
Van Eyken, Els (författare)
University of Antwerp, Belgium
Fransen, Erik (författare)
University of Antwerp, Belgium,Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUa Statistics Center, University of Antwerp, Antwerp, Belgium
Mäki-Torkko, Elina, 1961- (författare)
Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu; and Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Finland
Hannula, Samuli (författare)
University of Oulu and Oulu University Hospital, Finland,Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Finland
Parving, Agnete (författare)
Bispebjerg Hospital, Copenhagen, Denmark,Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland
Jensen, Mona (författare)
Bispebjerg Hospital, Copenhagen, Denmark,Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland
Tropitzsch, Anke (författare)
University of Tuebingen, Germany,Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark
Bonaconsa, Amanda (författare)
University Hospital Padova, Italy,Department of Otorhinolaryngology, University of Tubingen, Tubingen, Germany
Mazzoli, Manuela (författare)
University Hospital Padova, Italy,Department of Otorhinolaryngology, University of Tubingen, Tubingen, Germany
Espeso, Angeles (författare)
University Hospital of Wales, Cardiff, UK,Department of Otosurgery, University Hospital Padova, Padova, Italy
Verbruggen, Katia (författare)
University Hospital of Gent, Belgium
Huyghe, Joke (författare)
University Hospital of Gent, Belgium,Welsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom
Huygen, Patrick (författare)
Radboud University Nijmegen Medical Centre and Donders Institute for Brain, Cognition and Behaviour, the Netherlands
Kremer, Hannie (författare)
Radboud University Nijmegen Medical Centre, the Netherlands,Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands; Donders Institute for Brain, Cognition and Behaviour, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, Netherlands
Kunst, Sylvia (författare)
Radboud University Nijmegen Medical Centre, the Netherlands
Diaz-Lacava, Amalia (författare)
University of Bonn and German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Steffens, Michael (författare)
University of Bonn, Germany,Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Pyykkö, Ilmari (författare)
University of Tampere, Finland,Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
Dhooge, Ingeborg (författare)
University Hospital of Gent, Belgium,Welsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom
Stephens, Dafydd (författare)
University Hospital of Wales, Cardiff, UK,Department of Otosurgery, University Hospital Padova, Padova, Italy
Orzan, Eva (författare)
IRCCS ‘‘Burlo Garofolo,’’ Trieste, Italy,Audiology and Otolaryngology Unit, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
Pfister, Markus (författare)
University of Tuebingen, Germany
Bille, Mikael (författare)
Bispebjerg Hospital, Copenhagen, Denmark
Sorri, Martti (författare)
University of Oulu and Oulu University Hospital, Finland,Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Finland
Cremers, Cor (författare)
Radboud University Nijmegen Medical Centre, the Netherlands
Van Camp, Guy (författare)
University of Antwerp, Belgium
Van de Heyning, Paul (författare)
University Hospital of Antwerp, Belgium
Huyghe, Jeroen R. (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Eyken, Els Van (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Pfister, Markus H. F. (författare)
Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark
Verbruggen, Katja (författare)
Welsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom
Laer, Lut Van (författare)
de Heyning, Paul Van (författare)
University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
Camp, Guy Van (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Huygen, Patrick L. M. (författare)
Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands
Diaz-Lacava, Amalia N. (författare)
Pharmacoepidemiology in Neurodegenerative Disorders, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Cremers, Cor W. R. J. (författare)
Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands
Wienker, Thomas F. (författare)
Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Kunst, Sylvia J. (författare)
Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands
Bille, Michael (författare)
Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland
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 (creator_code:org_t)
Lippincott Williams & Wilkins, 2013
2013
Engelska.
Ingår i: Otology and Neurotology. - : Lippincott Williams & Wilkins. - 1531-7129 .- 1537-4505. ; 34:5, s. 838-844
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVE:To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated.STUDY DESIGN:Multicenter survey in 8 European centers.SUBJECTS:One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study.RESULTS:We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies.DISCUSSION:Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oto-rino-laryngologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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