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Sökning: onr:"swepub:oai:DiVA.org:liu-103305" > The ERK1/2 Signalin...

The ERK1/2 Signaling Pathway Is Involved in Sulfur Dioxide Preconditioning-Induced Protection against Cardiac Dysfunction in Isolated Perfused Rat Heart Subjected to Myocardial Ischemia/Reperfusion

Huang, Pan, (författare)
Peking University, Peoples R China
Sun, Yan, (författare)
Peking University, Peoples R China
Yang, Jinyan, (författare)
Peking University, Peoples R China
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Chen, Siyao, (författare)
Peking University, Peoples R China
Dong Liu, Angie, (författare)
Linköpings universitet, Institutionen för medicin och hälsa, Linköpings universitet, Hälsouniversitetet
Holmberg, Lukas, (författare)
Linköpings universitet, Institutionen för medicin och hälsa, Linköpings universitet, Hälsouniversitetet
Huang, Xiaomei, (författare)
Peking University, Peoples R China
Tang, Chaoshu, (författare)
Minist Educ, Peoples R China Peking University, Peoples R China
Du, Junbao, (författare)
Peking University, Peoples R China Minist Educ, Peoples R China
Jin, Hongfang, (författare)
Peking University, Peoples R China Minist Educ, Peoples R China
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Linköpings universitet Institutionen för medicin och hälsa. (creator_code:org_t)
Linköpings universitet Hälsouniversitetet. (creator_code:org_t)
2013
Engelska.
Ingår i: International Journal of Molecular Sciences. - MDPI. - 1422-0067. ; 14:11, s. 22190-22201
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Ischemia/reperfusion injury (IRI) occurs frequently during reperfusion of ischemic myocardium, and preconditioning has been regarded as one of the best strategies to prevent myocardial injury during the ischemia/reperfusion process. Our previous studies indicated that a small dose of sulfur dioxide (SO2) used as preconditioning exerts cardioprotection. However, the mechanisms underlying the cardioprotection remain unclear. The present study was designed to examine if the extracellular regulated protein kinases 1/2 (ERK1/2) signaling pathway mediated protection against cardiac dysfunction after SO2 preconditioning in isolated rat hearts subjected to ischemia/reperfusion (I/R). Langendorff heart perfusion was performed in vitro, where 56 male Wistar rats were randomly divided into seven groups: control group, 5 mol/L SO2 group (S5), 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (PD98059) + 5 mol/L SO2 (PD98059 + S5) group, PD98059 group, I/R group, 5 mol/L SO2 + I/R (S5 + I/R) group and PD98059 + 5 mol/L SO2 + I/R (PD98059 + S5 + I/R) group. Cardiac function and myocardial phosphorylated ERK1/2 protein were measured. We found that I/R in isolated rat heart resulted in cardiac dysfunction with a significant increase in phosphorylated ERK1/2 protein. SO2 preconditioning markedly suppressed phosphorylated ERK1/2 protein and improved cardiac function in isolated rat heart with I/R (p less than 0.05). However, pre-treatment with PD98059 could prevent the above effects of SO2 preconditioning. In conclusion, SO2 preconditioning protected against cardiac dysfunction in isolated rat heart subjected to I/R via suppression of the over-activation of the ERK1/2 signaling pathway.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

Nyckelord

myocardial ischemia; reperfusion injury; sulfur dioxide; preconditioning; mitogen activated protein kinase
MEDICINE
MEDICIN

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