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Clinical implications of the ISC technique for breast cancer radiotherapy and comparison with clinical recommendations

Flejmer, Anna M., (författare)
Linköpings universitet, Avdelningen för kliniska vetenskaper, Linköpings universitet, Hälsouniversitetet
Josefsson, Dan, (författare)
Linköpings universitet, Avdelningen för radiologiska vetenskaper, Linköpings universitet, Hälsouniversitetet, Östergötlands Läns Landsting, Radiofysikavdelningen US
Nilsson, Mats, (författare)
Futurum - Academy for Health and Care, Jönköping
visa fler...
Stenmarker, Margaretha, (författare)
Futurum - Academy for Health and Care, Jönköping
Dasu, Alexandru, (författare)
Linköpings universitet, Avdelningen för radiologiska vetenskaper, Linköpings universitet, Hälsouniversitetet, Östergötlands Läns Landsting, Radiofysikavdelningen US
visa färre...
2014
Engelska.
Ingår i: Anticancer Research. - International Institute of Anticancer Research. - 0250-7005 .- 1791-7530. ; 34:7, s. 3563-3568
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • <p><em>Purpose:</em> The project studied the implications of using the irregular surface compensator (ISC) technique in comparison to three-dimensional conformal radiation therapy (3D-CRT) for breast cancer treatment. ISC is an electronic compensation algorithm that modulates the fluence across the radiation fields to compensate for irregularly shaped surfaces and deliver a homogeneous dose to a compensation plane.<strong> </strong><em>Methods:</em> Ten breast cancer patients (five left- and five right-sided) were planned with both techniques. The planning was done for 50 Gy in 25 fractions with 2 Gy per fraction in all patients. Physical parameters such as doses to the clinical target volume (CTV-T) and the planned target volume (PTV), heterogeneity index and doses to lung and heart were determined and compared for the treatment plans.<strong> </strong><em>Results:</em> The ISC technique led to significantly better coverage of the CTV-T and PTV in almost all patients with statistically significant better homogeneity of the dose distribution. The contralateral lung and the heart receive the same doses with both ISC and 3D-CRT plans. However, ISC showed a trend towards decreasing the volumes of the ipsilateral lung irradiated with high doses. Consequently this led to better compliance with the national recommendations for breast radiotherapy.<strong> </strong><em>Conclusion:</em> The ISC technique leads to an improvement of the target coverage and the radiation burden of the ipsilateral lung thus allowing better compliance with the national recommendations and increasing the potential for improved quality of life for breast cancer patients. It should therefore be preferred over 3D-CRT for breast cases with difficult dose homogeneity to the PTV or CTV-T.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

breast radiotherapy
irregular surface compensator
fractionated radiotherapy
irradiation technique

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