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Autism and epilepsy :
Autism and epilepsy : A population-based nationwide cohort study
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- Sundelin, Heléne E. K. (författare)
- Department of Pediatrics, University Hospital, Linköping, Sweden,Region Östergötland, Barn- och ungdomskliniken i Linköping
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- Larsson, Henrik, 1975- (författare)
- Karolinska Institutet,Departments of Medical Epidemiology and Biostatistics, Karolinska Institute, Sweden
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- Lichtenstein, Paul (författare)
- Karolinska Institutet,Departments of Medical Epidemiology and Biostatistics, Karolinska Institute, Sweden
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- Almqvist, Catarina (författare)
- Karolinska Institutet,Departments of Medical Epidemiology and Biostatistics, Karolinska Institute, Sweden; Astrid Lindgren Children's Hospital, Karolinska University Hospital, Sweden
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- Hultman, Christina M. (författare)
- Karolinska Institutet,Departments of Medical Epidemiology and Biostatistics, Karolinska Institute, Sweden
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- Tomson, Torbjörn (författare)
- Karolinska Institutet,Clinical Neuroscience, Karolinska Institute, Sweden
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- Ludvigsson, Jonas F., 1969- (författare)
- Karolinska Institutet,Departments of Medical Epidemiology and Biostatistics, Karolinska Institute, Sweden; Department of Pediatrics, University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, UK
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(creator_code:org_t)
- Philadelphia, USA : Lippincott Williams & Wilkins, 2016
- 2016
- Engelska.
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Ingår i: Neurology. - Philadelphia, USA : Lippincott Williams & Wilkins. - 0028-3878 .- 1526-632X. ; 87:2, s. 192-197
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objective: To investigate the risk of autism spectrum disorder (ASD) in individuals with epilepsy and in their first-degree relatives to determine shared etiology.Methods: Through the Swedish Patient Register, we identified 85,201 individuals with epilepsy, as well as all their siblings (n = 80,511) and offspring (n = 98,534). Each individual with epilepsy was compared with 5 controls, matched for age, sex, calendar period, and county, while siblings and offspring were compared with siblings and offspring of controls. We excluded siblings and offspring with epilepsy. Using Cox regression, we calculated hazard ratios (HRs) for future diagnosis of ASD. Logistic regression was applied to calculate odds ratios (ORs) for prior diagnosis of ASD.Results: During follow-up, 1,381 (1.6%) individuals with epilepsy and 700 (0.2%) controls were diagnosed with ASD. Individuals with epilepsy were therefore at increased risk of future ASD (HR 10.49, 95% confidence interval [CI] 9.55-11.53), with the highest risk seen in individuals diagnosed with epilepsy in childhood. Both siblings (HR 1.62, 95% CI 1.43-1.83) and offspring (HR 1.64, 95% CI 1.46-1.84) of epilepsy patients were at increased risk of ASD. The risk in the offspring was particularly high in mothers with epilepsy (HR 1.91; 95% CI 1.63-2.23). Epilepsy was also associated with a prior diagnosis of ASD (OR 4.56, 95% CI 4.02-5.18).Conclusions: Individuals with epilepsy are at increased risk of ASD, especially if epilepsy appears in childhood. Further, ASD is more common in the siblings and offspring of individuals with epilepsy, suggesting shared etiology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
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