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Sökning: onr:"swepub:oai:DiVA.org:liu-134494" > Prevalence and Clin...

Prevalence and Clinical Significance of Diabetes in Asian Versus White Patients With Heart Failure

Bank, Ingrid E. M. (författare)
University of Medical Centre Utrecht, Netherlands
Gijsberts, Crystel M. (författare)
University of Medical Centre Utrecht, Netherlands; ICIN Netherlands Heart Institute, Netherlands
Teng, Tiew-Hwa K. (författare)
Singhealth, Singapore
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Benson, Lina (författare)
Karolinska Institute, Sweden
Sim, David (författare)
Singhealth, Singapore
Shuan Daniel Yeo, Poh (författare)
Tan Tock Seng Hospital, Singapore
Yee Ong, Hean (författare)
Khoo Teck Puat Hospital, Singapore
Jaufeerally, Fazlur (författare)
Singapore Gen Hospital, Singapore
Leong, Gerard K. T. (författare)
Changi Gen Hospital, Singapore
Ling, Lieng H. (författare)
National University, Singapore; National University of Health Syst, Singapore
Richards, A. Mark (författare)
National University, Singapore; University of Otago, New Zealand
de Kleijn, Dominique P. V. (författare)
University of Medical Centre Utrecht, Netherlands; National University, Singapore
Dahlström, Ulf (författare)
Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
Lund, Lars H. (författare)
Karolinska University Hospital, Sweden
Lam, Carolyn S. P. (författare)
Singhealth, Singapore; National University, Singapore; National University, Singapore; Duke NUS Medical Sch, Singapore
Yeo, PSD (författare)
Gijsberts, CM (författare)
Sim, D (författare)
Bank, IEM (författare)
Ling, LH (författare)
de Kleijn, DPV (författare)
Dahlstrom, U (författare)
Ong, HY (författare)
Leong, GKT (författare)
Richards, AM (författare)
Lam, CSP (författare)
Jaufeerally, F (författare)
Lund, LH (författare)
Karolinska Institutet
Teng, THK (författare)
Benson, L (författare)
Karolinska Institutet
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 (creator_code:org_t)
ELSEVIER SCI LTD, 2017
2017
Engelska.
Ingår i: JACC. Heart failure. - : ELSEVIER SCI LTD. - 2213-1779 .- 2213-1787. ; 5:1, s. 14-24
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVES The study sought to compare the prevalence, clinical correlates and prognostic impact of diabetes in Southeast Asian versus white patients with heart failure (HF) with preserved or reduced ejection fraction. BACKGROUND Diabetes mellitus is common in HF and is associated with impaired prognosis. Asia is home to the majority of the worlds diabetic population, yet data on the prevalence and clinical significance of diabetes in Asian patients with HF are sparse, and no studies have directly compared Asian and white patients. METHODS Two contemporary population-based HF cohorts were combined: from Singapore (n 1,002, median [25th to 75th percentile] age 62 [54 to 70] years, 76% men, 19.5% obesity) and Sweden (n =19,537, 77 [68 to 84] years, 60% men, 24.8% obesity). The modifying effect of ethnicity on the relationship between diabetes and clinical correlates or prognosis (HF hospitalization and all-cause mortality) was examined using interaction terms. RESULTS Diabetes was present in 569 (57%) Asian patients versus 4,680 (24%) white patients (p amp;lt; 0.001). Adjusting for clinical covariates, obesity was more strongly associated with diabetes in white patients (odds ratio [OR]: 3.45;. 95% confidence interval [CI]: 2.86 to 4.17) than in Asian patients (OR: 1.82; 95% CI: 1.13 to 2.96; P-interaction = 0.026). Diabetes was more strongly associated with increased HF hospitalization and all-cause mortality in Asian patients (hazard ratio: 1.50; 95% CI: 1.21 to 1.87) than in white patients (hazard ratio: 1.29; 95% CI: 1.22 to 1.36; P-interaction = 0.045). CONCLUSIONS Diabetes was 3-fold more common in Southeast Asian compared to white patients with HF, despite younger age and less obesity, and more strongly associated with poor outcomes in Asian patients than white patients. These results underscore the importance of ethnicity-tailored aggressive strategies to prevent diabetes and its complications. (C) 2017 by the American College of Cardiology Foundation.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

diabetes mellitus; global disease patterns; global health; heart failure with preserved ejection fraction; heart failure with reduced ejection fraction

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