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Signs of ongoing inflammation in female patients with chronic widespread pain A multivariate, explorative, cross-sectional study of blood samples

Gerdle, Björn, (författare)
Linkoping Univ, Pain & Rehabil Ctr, SE-58183 Linkoping, Sweden.;Linkoping Univ, Dept Med & Hlth Sci, SE-58183 Linkoping, Sweden.
Ghafouri, Bijar, (författare)
Linkoping Univ, Pain & Rehabil Ctr, SE-58183 Linkoping, Sweden.;Linkoping Univ, Dept Med & Hlth Sci, SE-58183 Linkoping, Sweden.
Ghafouri, Nazdar, (författare)
Linkoping Univ, Pain & Rehabil Ctr, SE-58183 Linkoping, Sweden.;Linkoping Univ, Dept Med & Hlth Sci, SE-58183 Linkoping, Sweden.
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Backryd, Emmanuel, (författare)
Linkoping Univ, Pain & Rehabil Ctr, SE-58183 Linkoping, Sweden.;Linkoping Univ, Dept Med & Hlth Sci, SE-58183 Linkoping, Sweden.
Gordh, Torsten, (författare)
Uppsala universitet, Anestesiologi och intensivvård
Bäckryd, Emmanuel, 1974- (författare)
Linköpings universitet, Avdelningen för samhällsmedicin, Linköpings universitet, Medicinska fakulteten, Region Östergötland, Smärt och rehabiliteringscentrum
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet. Medicinska fakulteten. Institutionen för kirurgiska vetenskaper. Anestesiologi och intensivvård. (creator_code:org_t)
Linköpings universitet Institutionen för medicin och hälsa. Avdelningen för samhällsmedicin. (creator_code:org_t)
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Linköpings universitet Medicinska fakulteten. (creator_code:org_t)
Region Östergötland Sinnescentrum. Smärt och rehabiliteringscentrum. (creator_code:org_t)
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2017
Engelska.
Ingår i: Medicine (Baltimore, Md.). - LIPPINCOTT WILLIAMS & WILKINS. - 0025-7974. ; 96:9
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • This cross-sectional study investigates the plasma inflammatory profile of chronic widespread pain CWP) patients compared to healthy controls CON). Rather than analyzing a relatively few substances at a time, we used a new multiplex proximity extension assay PEA) panel that enabled the simultaneous analysis of 92 inflammation-related proteins, mainly cytokines and chemokines. Seventeen women with CWP and 21 female CON participated and a venous blood sample was drawn from all subjects. Pain intensity and pain thresholds for pressure, heat, and cold were registered. A PEA panel 92 proteins) was used to analyze the blood samples. Multivariate data analysis by projection was used in the statistical analyses. Eleven proteins significantly differentiated the CON and CWP subjects R-2=0.58, Q(2)=0.37, analysis of variance of cross-validated predictive residuals P=0.006). It was not possible to significantly regress pain thresholds within each group CON or CWP). Positive significant correlations existed between several proteins and pain intensities in CWP, but the model reliability of the regression was poor. CWP was associated with systemic low-grade inflammation. Larger studies are needed to confirm the results and to investigate which alterations are condition-specific and which are common across chronic pain conditions. The presence of inflammation could promote the spreading of pain, a hallmark sign of CWP. As it has been suggested that prevalent comorbidities to pain (e.g., depression and anxiety, poor sleep, and tiredness) also are associated with inflammation, it will be important to determine whether inflammation may be a common mediator.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Allmän medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Family Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper -- Sjukgymnastik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Physiotherapy (hsv//eng)

Nyckelord

chemokine
cytokine
fibromyalgia
pain
widespread pain
chemokine; cytokine; fibromyalgia; pain; widespread pain

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