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Malignant Central Nervous System Tumors Among Adolescents and Young Adults (15-39 Years Old) in 14 Southern-Eastern European Registries and the US Surveillance, Epidemiology, and End Results Program: Mortality and Survival Patterns

Georgakis, Marios K. (författare)
University of Athens, Greece
Papathoma, Paraskevi (författare)
Region Östergötland, Neurologiska kliniken,University of Athens, Greece
Ryzhov, Anton (författare)
National Cancer Registry Ukraine, Ukraine
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Zivkovic-Perisic, Snezana (författare)
Institute Public Health Serbia, Serbia
Eser, Sultan (författare)
Izmir and Hacettepe University, Turkey
Taraszkiewicz, Lukasz (författare)
Greater Poland Cancer Centre, Poland
Sekerija, Mario (författare)
Croatian Institute Public Heatlh, Croatia
Zagar, Tina (författare)
Cancer Registry Republ Slovenia, Slovenia
Antunes, Luis (författare)
Portuguese Oncology Institute Porto, Portugal
Zborovskaya, Anna (författare)
Belarusian Research Center for Pediatric Oncology, Hematology, and Immunology, Childhood Cancer Subregistry of Belarus, Minsk, Belarus
Bastos, Joana (författare)
Portuguese Oncology Institute Coimbra, Portugal
Florea, Margareta (författare)
National Institute Public Heatlh, Romania
Coza, Daniela (författare)
Ion Chiricuta Oncology Institute, Romania
Demetriou, Anna (författare)
Childhood Cancer Subregistry Belarus, Byelarus; Minist Heatlh, Cyprus
Agius, Domenic (författare)
Malta National Cancer Registry, Malta
Strahinja, Rajko M. (författare)
Institute Public Heatlh, Montenegro
Themistocleous, Marios (författare)
Aghia Sophia Childrens Hospital, Greece
Tolia, Maria (författare)
University of Athens, Greece
Tzanis, Spyridon (författare)
Errikos Dunant Hospital Centre, Greece
Alexiou, George A. (författare)
Ioannina University, Greece
Papanikolaou, Panagiotis G. (författare)
Gen Nikaia Piraeus Hospital, Greece
Nomikos, Panagiotis (författare)
Hygeia Hospital, Greece
Kantzanou, Maria (författare)
University of Athens, Greece
Dessypris, Nick (författare)
University of Athens, Greece
Pourtsidis, Apostolos (författare)
Panagiotis and Aglaia Kyriakou Childrens Hospital, Greece
Petridou, Eleni T. (författare)
University of Athens, Greece; Karolinska Institute, Sweden
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WILEY, 2017
Ingår i: Cancer. - : WILEY. - 0008-543X .- 1097-0142. ; 123:22, s. 4458-4471
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
  • BACKGROUND: Unique features and worse outcomes have been reported for cancers among adolescents and young adults (AYAs; 15-39 years old). The aim of this study was to explore the mortality and survival patterns of malignant central nervous system (CNS) tumors among AYAs in Southern-Eastern Europe (SEE) in comparison with the US Surveillance, Epidemiology, and End Results (SEER) program. METHODS: Malignant CNS tumors diagnosed in AYAs during the period spanning 1990-2014 were retrieved from 14 population-based cancer registries in the SEE region (n = 11,438). Age-adjusted mortality rates were calculated and survival patterns were evaluated via Kaplan-Meier curves and Cox regression analyses, and they were compared with respective 1990-2012 figures from SEER (n = 13,573). RESULTS: Mortality rates in SEE (range, 11.9-18.5 deaths per million) were higher overall than the SEER rate (9.4 deaths per million), with decreasing trends in both regions. Survival rates increased during a comparable period (2001-2009) in SEE and SEER. The 5-year survival rate was considerably lower in the SEE registries (46%) versus SEER (67%), mainly because of the extremely low rates in Ukraine; this finding was consistent across age groups and diagnostic subtypes. The highest 5-year survival rates were recorded for ependymomas (76% in SEE and 92% in SEER), and the worst were recorded for glioblastomas and anaplastic astrocytomas (28% in SEE and 37% in SEER). Advancing age, male sex, and rural residency at diagnosis adversely affected outcomes in both regions. CONCLUSIONS: Despite definite survival gains over the last years, the considerable outcome disparities between the less affluent SEE region and the United States for AYAs with malignant CNS tumors point to health care delivery inequalities. No considerable prognostic deficits for CNS tumors are evident for AYAs versus children. (c) 2017 American Cancer Society.


MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)


adolescents and young adults; brain tumors; central nervous system tumors; epidemiology; mortality; outcome; survival

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