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Sökning: onr:"swepub:oai:DiVA.org:liu-143069" > Malignant Central N...

  • Georgakis, Marios K.,University of Athens, Greece (författare)

Malignant Central Nervous System Tumors Among Adolescents and Young Adults (15-39 Years Old) in 14 Southern-Eastern European Registries and the US Surveillance, Epidemiology, and End Results Program: Mortality and Survival Patterns

  • Artikel/kapitelEngelska2017


  • LIBRIS-ID:oai:DiVA.org:liu-143069
  • 10.1002/cncr.30884doi
  • 28708937pmid
  • urn:nbn:se:liu:diva-143069urn

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype


  • Published
  • 26
  • <p>BACKGROUND: Unique features and worse outcomes have been reported for cancers among adolescents and young adults (AYAs; 15-39 years old). The aim of this study was to explore the mortality and survival patterns of malignant central nervous system (CNS) tumors among AYAs in Southern-Eastern Europe (SEE) in comparison with the US Surveillance, Epidemiology, and End Results (SEER) program. METHODS: Malignant CNS tumors diagnosed in AYAs during the period spanning 1990-2014 were retrieved from 14 population-based cancer registries in the SEE region (n = 11,438). Age-adjusted mortality rates were calculated and survival patterns were evaluated via Kaplan-Meier curves and Cox regression analyses, and they were compared with respective 1990-2012 figures from SEER (n = 13,573). RESULTS: Mortality rates in SEE (range, 11.9-18.5 deaths per million) were higher overall than the SEER rate (9.4 deaths per million), with decreasing trends in both regions. Survival rates increased during a comparable period (2001-2009) in SEE and SEER. The 5-year survival rate was considerably lower in the SEE registries (46%) versus SEER (67%), mainly because of the extremely low rates in Ukraine; this finding was consistent across age groups and diagnostic subtypes. The highest 5-year survival rates were recorded for ependymomas (76% in SEE and 92% in SEER), and the worst were recorded for glioblastomas and anaplastic astrocytomas (28% in SEE and 37% in SEER). Advancing age, male sex, and rural residency at diagnosis adversely affected outcomes in both regions. CONCLUSIONS: Despite definite survival gains over the last years, the considerable outcome disparities between the less affluent SEE region and the United States for AYAs with malignant CNS tumors point to health care delivery inequalities. No considerable prognostic deficits for CNS tumors are evident for AYAs versus children. (c) 2017 American Cancer Society.</p>

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Papathoma, Paraskevi,Region Östergötland, Neurologiska kliniken, University of Athens, Greece(SwePub:) (författare)
  • Ryzhov, Anton,National Cancer Registry Ukraine, Ukraine(SwePub:) (författare)
  • Zivkovic-Perisic, Snezana,Institute Public Health Serbia, Serbia(SwePub:) (författare)
  • Eser, Sultan,Izmir and Hacettepe University, Turkey(SwePub:) (författare)
  • Taraszkiewicz, Lukasz,Greater Poland Cancer Centre, Poland(SwePub:) (författare)
  • Sekerija, Mario,Croatian Institute Public Heatlh, Croatia(SwePub:) (författare)
  • Zagar, Tina,Cancer Registry Republ Slovenia, Slovenia(SwePub:) (författare)
  • Antunes, Luis,Portuguese Oncology Institute Porto, Portugal(SwePub:) (författare)
  • Zborovskaya, Anna,Belarusian Research Center for Pediatric Oncology, Hematology, and Immunology, Childhood Cancer Subregistry of Belarus, Minsk, Belarus(SwePub:) (författare)
  • Bastos, Joana,Portuguese Oncology Institute Coimbra, Portugal(SwePub:) (författare)
  • Florea, Margareta,National Institute Public Heatlh, Romania(SwePub:) (författare)
  • Coza, Daniela,Ion Chiricuta Oncology Institute, Romania(SwePub:) (författare)
  • Demetriou, Anna,Childhood Cancer Subregistry Belarus, Byelarus; Minist Heatlh, Cyprus(SwePub:) (författare)
  • Agius, Domenic,Malta National Cancer Registry, Malta(SwePub:) (författare)
  • Strahinja, Rajko M.,Institute Public Heatlh, Montenegro(SwePub:) (författare)
  • Themistocleous, Marios,Aghia Sophia Childrens Hospital, Greece(SwePub:) (författare)
  • Tolia, Maria,University of Athens, Greece(SwePub:) (författare)
  • Tzanis, Spyridon,Errikos Dunant Hospital Centre, Greece(SwePub:) (författare)
  • Alexiou, George A.,Ioannina University, Greece(SwePub:) (författare)
  • Papanikolaou, Panagiotis G.,Gen Nikaia Piraeus Hospital, Greece(SwePub:) (författare)
  • Nomikos, Panagiotis,Hygeia Hospital, Greece(SwePub:) (författare)
  • Kantzanou, Maria,University of Athens, Greece(SwePub:) (författare)
  • Dessypris, Nick,University of Athens, Greece(SwePub:) (författare)
  • Pourtsidis, Apostolos,Panagiotis and Aglaia Kyriakou Childrens Hospital, Greece(SwePub:) (författare)
  • Petridou, Eleni T.,University of Athens, Greece; Karolinska Institute, Sweden(SwePub:) (författare)

Sammanhörande titlar

  • Ingår i:CancerWILEY0008-543X1097-0142123:22, s. 4458-4471


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  • Cancer (Sök värdpublikationen i LIBRIS)

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