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Sökning: onr:"swepub:oai:DiVA.org:liu-148381" > Postmastectomy Radi...

Postmastectomy Radiation Therapy in Women with T1-T2 Tumors and 1 to 3 Positive Lymph Nodes: Analysis of the Breast International Group 02-98 Trial

Zeidan, Youssef H. (författare)
Amer Univ Beirut, Lebanon
Habib, Joyce G. (författare)
Fouad Khoury and Makassed Gen Hosp, Lebanon; Univ Libre Bruxelles, Belgium
Ameye, Lieveke (författare)
Universite´Libre de Bruxelles, Brussels, Belgium
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Paesmans, Marianne (författare)
Universite´Libre de Bruxelles, Brussels, Belgium
de Azambuja, Evandro (författare)
Univ Libre Bruxelles, Belgium
Gelber, Richard D. (författare)
Harvard Med Sch, MA USA; Frontier Sci and Technol Res Fdn Inc, MA USA
Campbell, Ian (författare)
Univ Auckland, New Zealand
Nordenskjöld, Bo (författare)
Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
Gutierez, Jorge (författare)
Clin Los Condes, Chile
Anderson, Michael (författare)
Copenhagen Univ Hosp, Denmark; Danish Breast Canc Cooperat Grp, Denmark
Lluch, Ana (författare)
Univ Valencia, Spain
Gnant, Michael (författare)
Med Univ Vienna, Austria; Austrian Breast and Colorectal Canc Study Grp, Austria
Goldhirsch, Aron (författare)
European Inst Oncol, Italy; Int Breast Canc Study Grp, Switzerland
Di Leo, Angelo (författare)
Hosp Prato, Italy
Joseph, David J. (författare)
Univ Western Australia, Australia; Edith Cowan Univ, Australia; Breast Canc Trials Australia and New Zealand, Australia
Crown, John (författare)
St Vincents Univ Hosp, Ireland
Piccart-Gebhart, Martine (författare)
Univ Libre Bruxelles, Belgium
Francis, Prudence A. (författare)
Int Breast Canc Study Grp, Switzerland; Peter MacCallum Canc Ctr, Australia; Univ Melbourne, Australia; Univ Newcastle, Australia
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 (creator_code:org_t)
ELSEVIER SCIENCE INC, 2018
2018
Engelska.
Ingår i: International Journal of Radiation Oncology, Biology, Physics. - : ELSEVIER SCIENCE INC. - 0360-3016 .- 1879-355X. ; 101:2, s. 316-324
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Purpose: To analyze the impact of postmastectomy radiation therapy (PMRT) for patients with T1-T2 tumors and 1 to 3 positive lymph nodes enrolled on the Breast International Group (BIG) 02-98 trial. Methods and Materials: The BIG 02-98 trial randomized patients to receive adjuvant anthracycline with or without taxane chemotherapy. Delivery of PMRT was nonrandomized and performed according to institutional preferences. The present analysis was performed on participants with T1-T2 breast cancer and 1 to 3 positive lymph nodes who had undergone mastectomy and axillary nodal dissection. The primary objective of the present study was to examine the effect of PMRT on risk of locoregional recurrence (LRR), breast cancer-specific survival, and overall survival. Results: We identified 684 patients who met the inclusion criteria and were included in the analysis, of whom 337 (49%) had received PMRT. At 10 years, LRR risk was 2.5% in the PMRT group and 6.5% in the no-PMRT group (hazard ratio 0.29, 95% confidence interval 0.12-0.73; P=.005). Lower LRR after PMRT was noted for patients randomized to receive adjuvant chemotherapy with no taxane (10-year LRR: 3.4% vs 9.1%; P=.02). No significant differences in breast cancer-specific survival (84.3% vs 83.9%) or overall survival (81.7% vs 78.3%) were observed according to receipt of PMRT. Conclusion: Our analysis of the BIG02-98 trial shows excellent outcomes in women with T1-T2 tumors and 1 to 3 positive lymph nodes found in axillary dissection. Although PMRT improved LRR in this cohort, the number of events remained low at 10 years. In all groups, 10-year rates of LRR were relatively low compared with historical studies. As such, the use of PMRT in women with 1 to 3 positive nodes should be tailored to individual patient risks. (C) 2018 Elsevier Inc. All rights reserved.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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