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Sökning: onr:"swepub:oai:DiVA.org:liu-148381" > Postmastectomy Radi...

  • Zeidan, Youssef H.Amer Univ Beirut, Lebanon (författare)

Postmastectomy Radiation Therapy in Women with T1-T2 Tumors and 1 to 3 Positive Lymph Nodes: Analysis of the Breast International Group 02-98 Trial

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • ELSEVIER SCIENCE INC,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-148381
  • urn:nbn:se:liu:diva-148381urn
  • https://doi.org/10.1016/j.ijrobp.2018.01.105DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Sanofi-Aventis; National Health and Medical Research Council [100925, 351164]
  • Purpose: To analyze the impact of postmastectomy radiation therapy (PMRT) for patients with T1-T2 tumors and 1 to 3 positive lymph nodes enrolled on the Breast International Group (BIG) 02-98 trial. Methods and Materials: The BIG 02-98 trial randomized patients to receive adjuvant anthracycline with or without taxane chemotherapy. Delivery of PMRT was nonrandomized and performed according to institutional preferences. The present analysis was performed on participants with T1-T2 breast cancer and 1 to 3 positive lymph nodes who had undergone mastectomy and axillary nodal dissection. The primary objective of the present study was to examine the effect of PMRT on risk of locoregional recurrence (LRR), breast cancer-specific survival, and overall survival. Results: We identified 684 patients who met the inclusion criteria and were included in the analysis, of whom 337 (49%) had received PMRT. At 10 years, LRR risk was 2.5% in the PMRT group and 6.5% in the no-PMRT group (hazard ratio 0.29, 95% confidence interval 0.12-0.73; P=.005). Lower LRR after PMRT was noted for patients randomized to receive adjuvant chemotherapy with no taxane (10-year LRR: 3.4% vs 9.1%; P=.02). No significant differences in breast cancer-specific survival (84.3% vs 83.9%) or overall survival (81.7% vs 78.3%) were observed according to receipt of PMRT. Conclusion: Our analysis of the BIG02-98 trial shows excellent outcomes in women with T1-T2 tumors and 1 to 3 positive lymph nodes found in axillary dissection. Although PMRT improved LRR in this cohort, the number of events remained low at 10 years. In all groups, 10-year rates of LRR were relatively low compared with historical studies. As such, the use of PMRT in women with 1 to 3 positive nodes should be tailored to individual patient risks. (C) 2018 Elsevier Inc. All rights reserved.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Habib, Joyce G.Fouad Khoury and Makassed Gen Hosp, Lebanon; Univ Libre Bruxelles, Belgium (författare)
  • Ameye, LievekeUniversite´Libre de Bruxelles, Brussels, Belgium (författare)
  • Paesmans, MarianneUniversite´Libre de Bruxelles, Brussels, Belgium (författare)
  • de Azambuja, EvandroUniv Libre Bruxelles, Belgium (författare)
  • Gelber, Richard D.Harvard Med Sch, MA USA; Frontier Sci and Technol Res Fdn Inc, MA USA (författare)
  • Campbell, IanUniv Auckland, New Zealand (författare)
  • Nordenskjöld, BoLinköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)bono64 (författare)
  • Gutierez, JorgeClin Los Condes, Chile (författare)
  • Anderson, MichaelCopenhagen Univ Hosp, Denmark; Danish Breast Canc Cooperat Grp, Denmark (författare)
  • Lluch, AnaUniv Valencia, Spain (författare)
  • Gnant, MichaelMed Univ Vienna, Austria; Austrian Breast and Colorectal Canc Study Grp, Austria (författare)
  • Goldhirsch, AronEuropean Inst Oncol, Italy; Int Breast Canc Study Grp, Switzerland (författare)
  • Di Leo, AngeloHosp Prato, Italy (författare)
  • Joseph, David J.Univ Western Australia, Australia; Edith Cowan Univ, Australia; Breast Canc Trials Australia and New Zealand, Australia (författare)
  • Crown, JohnSt Vincents Univ Hosp, Ireland (författare)
  • Piccart-Gebhart, MartineUniv Libre Bruxelles, Belgium (författare)
  • Francis, Prudence A.Int Breast Canc Study Grp, Switzerland; Peter MacCallum Canc Ctr, Australia; Univ Melbourne, Australia; Univ Newcastle, Australia (författare)
  • Amer Univ Beirut, LebanonFouad Khoury and Makassed Gen Hosp, Lebanon; Univ Libre Bruxelles, Belgium (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Radiation Oncology, Biology, Physics: ELSEVIER SCIENCE INC101:2, s. 316-3240360-30161879-355X

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