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Sökning: onr:"swepub:oai:DiVA.org:liu-155010" > Early tumor regrowt...

Early tumor regrowth is a contributor to impaired survival in patients with completely resected advanced ovarian cancer. An exploratory analysis of the Intergroup trial AGO-OVAR 12

Heitz, F. (författare)
Evangelische Huyssens Stiftung, Germany; Charite Univ Med Berlin, Germany; Free Univ Berlin, Germany; Humboldt Unive Berlin, Germany; Berlin Inst Hlth, Germany; AGO Study Grp, Germany
Harter, P. (författare)
Evangelische Huyssens Stiftung, Germany; AGO Study Grp, Germany
Åvall-Lundqvist, Elisabeth, Professor, 1957- (författare)
Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Karolinska Inst, Linkoping, Sweden; NSGO Study Grp, Germany
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Reuss, A. (författare)
Coordinating Ctr Clin Trials, Germany; AGO Study Grp, Germany
Pautier, P. (författare)
Inst Gustave Roussy, France; GINECO Study Grp, Germany
Cormio, G. (författare)
Univ Bari, Italy; Natl Canc Inst Giovanni Paolo II, Italy; MITO Study Grp, Germany
Colombo, N. (författare)
Univ Milano Bicocca, Italy; Inst Europeo Oncol, Italy; MaNGO Study Grp, Germany
Reinthaller, A. (författare)
Med Univ Vienna, Austria; AGO Austria Study Grp, Austria
Vergote, I. (författare)
Univ Leuven, Belgium; BGOG Study Grp, Austria
Poveda, A. (författare)
Inst Valenciano Oncol, Spain; GEICO Study Grp, Spain
Ottevanger, P. B. (författare)
Radboud Univ Nijmegen, Netherlands; DGOG Study Grp, Spain
Hanker, L. C. (författare)
Univ Schleswig Holstein, Germany; AGO Study Grp, Germany
Leminen, A. (författare)
Womens Hosp Med Ctr, Finland; NSGO Study Grp, Germany
Alexandre, J. (författare)
Hop Univ Paris Ctr, France; GINECO Study Grp, Germany
Canzler, U. (författare)
Tech Univ Dresden, Germany; AGO Study Grp, Germany
Sehouli, J. (författare)
Charite Campus Virchow Klinikum, Germany; AGO Study Grp, Germany
Herrstedt, J. (författare)
Odense Univ Hosp, Denmark; Zealand Univ, Denmark; NSGO Study Grp, Germany
Fiane, B. (författare)
Stavanger Univ Hosp, Norway; NSGO Study Grp, Germany
Merger, M. (författare)
Boehringer Ingelheim Pharma GmbH and Co KG, Germany
du Bois, A. (författare)
AGO Study Grp, Germany
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 (creator_code:org_t)
ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019
2019
Engelska.
Ingår i: Gynecologic Oncology. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0090-8258 .- 1095-6859. ; 152:2, s. 235-242
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Objective. Surgical assessment of residual tumor provides the strongest prognostic information in advanced ovarian cancer (AOC), with the best outcome observed after complete resection. Postoperative radiological assessment before initiation of chemotherapy can supplement the information obtained by surgical assessment; however, it may also reveal conflicting findings. Methods. Patients with AOC enrolled in the AGO-OVAR 12 trial underwent baseline imaging before the first chemotherapy cycle. The findings from surgical and radiologic assessment for disease extend were compared. Additionally, an integrated approach was assessed. Results. Complete data from all 3 assessment methods were available for 1345 patients. Of 689 patients with complete resection, tumor was observed in 28% and 22% of patients undergoing radiologic and integrated assessment, respectively. Patients with surgical- radiological and surgical-integrated concordant findings showed a 5-year overall survival (5Y-OS) of 72% and 71%, whereas patients with surgical-radiological and surgical-integrated discordant results showed inferior 5Y-OS of 47% and 49%, respectively. Patients with surgically assessed residual disease had a 5-YOS of 37%. The interval between surgery and baseline assessment was independently associated with discordance between assessment methods, which might reflect early tumor regrowth. Conclusions. Baseline tumor assessment before chemotherapy provides information that stratifies patients with complete resection into different prognostic groups. Integrating the data from different assessment methods might lead to improved definitions of prognostic groups. Further investigation to determine if earlier initiation of chemotherapy after debulking surgery could increase survival of patients with early tumor regrowth is warranted. (C) 2018 Published by Elsevier Inc.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Advanced ovarian cancer; Debulking surgery; Pre-chemotherapy imaging; Prognosis

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