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Sökning: onr:"swepub:oai:DiVA.org:liu-170002" > Excess Morbidity Pe...

Excess Morbidity Persists in Patients With Cushings Disease During Long-term Remission: A Swedish Nationwide Study

Papakokkinou, Eleni (författare)
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
Olsson, Daniel S. (författare)
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
Chantzichristos, Dimitrios (författare)
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Dahlqvist, Per (författare)
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
Segerstedt, Elin (författare)
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
Olsson, Tommy (författare)
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
Petersson, Maria (författare)
Department of Molecular Medicine and Surgery, Karolinska Institutet and The Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden
Berinder, Katarina (författare)
Department of Molecular Medicine and Surgery, Karolinska Institutet and The Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden
Bensing, Sophie (författare)
Department of Molecular Medicine and Surgery, Karolinska Institutet and The Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden
Höybye, Charlotte (författare)
Department of Molecular Medicine and Surgery, Karolinska Institutet and The Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden
Eden-Engström, Britt (författare)
Department of Medical Sciences; Endocrinology, Diabetes and Metabolism, Uppsala University Hospital, Uppsala, Sweden
Burman, Pia (författare)
Department of Medical Sciences; Endocrinology, Diabetes and Metabolism, Uppsala University Hospital, Uppsala, Sweden
Bonelli, Lorenza (författare)
Department of Endocrinology, Skåne University Hospital, University of Lund, Malmö, Sweden
Follin, Cecilia (författare)
Department of Endocrinology, Skåne University Hospital, Lund, Sweden
Petranek, David (författare)
Department of Endocrinology, Skåne University Hospital, Lund, Sweden
Erfurth, Eva Marie (författare)
Department of Endocrinology, Skåne University Hospital, Lund, Sweden
Wahlberg, Jeanette, 1969- (författare)
Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken
Ekman, Bertil, 1958- (författare)
Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken
Åkerman, Anna-Karin (författare)
Department of Internal Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden
Schwarcz, Erik (författare)
Department of Internal Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden
Bryngelsson, Ing-Liss (författare)
Department of Occupational and Environmental Medicine, University Hospital, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Johannsson, Gudmundur (författare)
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
Ragnarsson, Oskar (författare)
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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 (creator_code:org_t)
ENDOCRINE SOC, 2020
2020
Engelska.
Ingår i: Journal of Clinical Endocrinology and Metabolism. - : ENDOCRINE SOC. - 0021-972X .- 1945-7197. ; 105:8, s. 2616-2624
Relaterad länk:
https://doi.org/10.1...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Context: Whether multisystem morbidity in Cushings disease (CD) remains elevated during long-term remission is still undetermined. Objective: To investigate comorbidities in patients with CD. Design, Setting, and Patients: A retrospective, nationwide study of patients with CD identified in the Swedish National Patient Register between 1987 and 2013. Individual medical records were reviewed to verify diagnosis and remission status. Main Outcomes: Standardized incidence ratios (SIRs) with 95% confidence intervals (Os) were calculated by using the Swedish general population as reference. Comorbidities were investigated during three different time periods: (i) during the 3 years before diagnosis, (ii) from diagnosis to 1 year after remission, and (iii) during long-term remission. Results: We included 502 patients with confirmed CD, of whom 419 were in remission for a median of 10 (interquartile range 4 to 21) years. SIRs (95% CI) for myocardial infarction (4.4; 1.2 to 11.4), fractures (4.9; 2.7 to 8.3), and deep vein thrombosis (13.8; 3.8 to 35.3) were increased during the 3-year period before diagnosis. From diagnosis until 1 year after remission, SIRs (95% CI were increased for thromboembolism (18.3; 7.9 to 36.0), stroke (4.9; 1.3 to 12.5), and sepsis (13.6; 3.7 to 34.8). SIRs for thromboembolism (4.9; 2.6 to 8.4), stroke (3.1; 1.8 to 4.9), and sepsis (6.0; 3.1 to 10.6) remained increased during long-term remission. Conclusion: Patients with CD have an increased incidence of stroke, thromboembolism, and sepsis even after remission, emphasizing the importance of early identification and management of risk factors for these comorbidities during long-term follow-up.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Cushings disease; remission; comorbidity; cardiovascular; thromboembolism; sepsis

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