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Sökning: onr:"swepub:oai:DiVA.org:liu-170189" > Distribution of his...

Distribution of histopathological features along the colon in microscopic colitis

Fiehn, Anne-Marie Kanstrup (författare)
Zealand Univ Hosp, Denmark; Univ Copenhagen, Denmark
Miehlke, Stephan (författare)
Univ Hosp Eppendorf, Germany; Univ Hosp Eppendorf, Germany
Aust, Daniela (författare)
Univ Hosp Dresden, Germany
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Vieth, Michael (författare)
Klinikum Bayreuth, Germany
Bonderup, Ole (författare)
Silkeborg Hosp, Denmark
Fernandez-Banares, Fernando (författare)
Hosp Univ Mutua Terrassa, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain
Mihaly, Emese (författare)
Semmelweis Univ, Hungary
Kupcinskas, Juozas (författare)
Lithuanian Univ Hlth Sci, Lithuania
Madisch, Ahmed (författare)
CRH Clin Siloah, Germany
Munck, Lars Kristian (författare)
Univ Copenhagen, Denmark; Zealand Univ Hosp, Denmark
Nacak, Tanju (författare)
Dr Falk Pharma GmbH, Germany
Mohrbacher, Ralf (författare)
Dr Falk Pharma GmbH, Germany
Mueller, Ralph (författare)
Dr Falk Pharma GmbH, Germany
Greinwald, Roland (författare)
Dr Falk Pharma GmbH, Germany
Münch, Andreas (författare)
Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken
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 (creator_code:org_t)
Springer, 2020
2020
Engelska.
Ingår i: International Journal of Colorectal Disease. - : Springer. - 0179-1958 .- 1432-1262.
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Purpose The diagnosis microscopic colitis (MC) consisting of collagenous colitis (CC) and lymphocytic colitis (LC) relies on histological assessment of mucosal biopsies from the colon. The optimal biopsy strategy for reliable diagnosis of MC is controversial. The aim of this study was to evaluate the distribution of histopathological features of MC throughout the colon. Methods Mucosal biopsies from multiple colonic segments of patients with MC who participated in one of the three prospective European multicenter trials were analyzed. Histological slides were stained with hematoxylin-and-eosin, a connective tissue stain, and CD3 in selected cases. Results In total, 255 patients were included, 199 and 56 patients with CC and LC, respectively. Both groups exhibited a gradient with more pronounced inflammation in the lamina propria in the proximal colon compared with the distal colon. Similarly, the thickness of the subepithelial collagenous band in CC showed a gradient with higher values in the proximal colon. The mean number of intraepithelial lymphocytes was > 20 in all colonic segments in patients within both subgroups. Biopsies from 86 to 94% of individual segments were diagnostic, rectum excluded. Biopsies from non-diagnostic segments often showed features of another subgroup of MC. Conclusion Conclusively, although the severity of the histological changes in MC differed in the colonic mucosa, the minimum criteria required for the diagnosis were present in the random biopsies from the majority of segments. Thus, our findings show MC to be a pancolitis, rectum excluded, questioning previously proclaimed patchiness throughout the colon.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Colonic biopsies; Histopathology; Histology; Diagnosis; Chronic diarrhea; Inflammatory bowel disease; Microscopic colitis

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