SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:liu-170189"
 

Sökning: onr:"swepub:oai:DiVA.org:liu-170189" > Distribution of his...

  • Fiehn, Anne-Marie KanstrupZealand Univ Hosp, Denmark; Univ Copenhagen, Denmark (författare)

Distribution of histopathological features along the colon in microscopic colitis

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • Springer,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-170189
  • urn:nbn:se:liu:diva-170189urn
  • https://doi.org/10.1007/s00384-020-03747-zDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Purpose The diagnosis microscopic colitis (MC) consisting of collagenous colitis (CC) and lymphocytic colitis (LC) relies on histological assessment of mucosal biopsies from the colon. The optimal biopsy strategy for reliable diagnosis of MC is controversial. The aim of this study was to evaluate the distribution of histopathological features of MC throughout the colon. Methods Mucosal biopsies from multiple colonic segments of patients with MC who participated in one of the three prospective European multicenter trials were analyzed. Histological slides were stained with hematoxylin-and-eosin, a connective tissue stain, and CD3 in selected cases. Results In total, 255 patients were included, 199 and 56 patients with CC and LC, respectively. Both groups exhibited a gradient with more pronounced inflammation in the lamina propria in the proximal colon compared with the distal colon. Similarly, the thickness of the subepithelial collagenous band in CC showed a gradient with higher values in the proximal colon. The mean number of intraepithelial lymphocytes was > 20 in all colonic segments in patients within both subgroups. Biopsies from 86 to 94% of individual segments were diagnostic, rectum excluded. Biopsies from non-diagnostic segments often showed features of another subgroup of MC. Conclusion Conclusively, although the severity of the histological changes in MC differed in the colonic mucosa, the minimum criteria required for the diagnosis were present in the random biopsies from the majority of segments. Thus, our findings show MC to be a pancolitis, rectum excluded, questioning previously proclaimed patchiness throughout the colon.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Miehlke, StephanUniv Hosp Eppendorf, Germany; Univ Hosp Eppendorf, Germany (författare)
  • Aust, DanielaUniv Hosp Dresden, Germany (författare)
  • Vieth, MichaelKlinikum Bayreuth, Germany (författare)
  • Bonderup, OleSilkeborg Hosp, Denmark (författare)
  • Fernandez-Banares, FernandoHosp Univ Mutua Terrassa, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain (författare)
  • Mihaly, EmeseSemmelweis Univ, Hungary (författare)
  • Kupcinskas, JuozasLithuanian Univ Hlth Sci, Lithuania (författare)
  • Madisch, AhmedCRH Clin Siloah, Germany (författare)
  • Munck, Lars KristianUniv Copenhagen, Denmark; Zealand Univ Hosp, Denmark (författare)
  • Nacak, TanjuDr Falk Pharma GmbH, Germany (författare)
  • Mohrbacher, RalfDr Falk Pharma GmbH, Germany (författare)
  • Mueller, RalphDr Falk Pharma GmbH, Germany (författare)
  • Greinwald, RolandDr Falk Pharma GmbH, Germany (författare)
  • Münch, AndreasLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)andsa76 (författare)
  • Zealand Univ Hosp, Denmark; Univ Copenhagen, DenmarkUniv Hosp Eppendorf, Germany; Univ Hosp Eppendorf, Germany (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Colorectal Disease: Springer0179-19581432-1262

Internetlänk

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy