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Sökning: onr:"swepub:oai:DiVA.org:liu-174557" > Modeling psychologi...

Modeling psychological function in patients with schizophrenia with the PANSS : An international multi-center study

Fountoulakis, K.N. (författare)
Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
Dragioti, Elena, Ph.D. (författare)
Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Sweden
Theofilidis, A.T. (författare)
3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
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Wiklund, Tobias, 1986- (författare)
Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Huddinge, Sweden
Atmatzidis, Xenofon (författare)
Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Huddinge, Sweden
Nimatoudis, I. (författare)
3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
Thys, E. (författare)
University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium
Wampers, M. (författare)
University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium; Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium
Hranov, L. (författare)
University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry sveti Naum, Sofia, Bulgaria
Hristova, T. (författare)
University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry sveti Naum, Sofia, Bulgaria
Aptalidis, D. (författare)
University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry sveti Naum, Sofia, Bulgaria
Milev, R. (författare)
Department of Psychiatry, Queens University, Providence Care Hospital, Kingston, ON, Canada
Iftene, F. (författare)
Department of Psychiatry, Queens University, Providence Care Hospital, Kingston, ON, Canada
Spaniel, F. (författare)
National Institute of Mental Health, Klecany, Czech Republic
Knytl, P. (författare)
National Institute of Mental Health, Klecany, Czech Republic
Furstova, P. (författare)
National Institute of Mental Health, Klecany, Czech Republic
From, T. (författare)
Department of Psychiatry, University of Turku, Turku, Finland
Karlsson, H. (författare)
Department of Psychiatry, University of Turku, Turku, Finland
Walta, M. (författare)
Department of Psychiatry, University of Turku, Turku, Finland
Salokangas, R.K.R. (författare)
Department of Psychiatry, University of Turku, Turku, Finland
Azorin, J.-M. (författare)
Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France; Timone Institute of Neuroscience, Marseille, France
Bouniard, J. (författare)
Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France; Timone Institute of Neuroscience, Marseille, France
Montant, J. (författare)
Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France; Timone Institute of Neuroscience, Marseille, France
Juckel, G. (författare)
Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
Haussleiter, I.S. (författare)
Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
Douzenis, A. (författare)
2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece
Michopoulos, I. (författare)
2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece
Ferentinos, P. (författare)
2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece
Smyrnis, N. (författare)
Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece
Mantonakis, L. (författare)
Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece
Nemes, Z. (författare)
Nyír Gyula Hospital, Budapest, Hungary
Gonda, X. (författare)
Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
Vajda, D. (författare)
Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
Juhasz, A. (författare)
Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
Shrivastava, A. (författare)
Western University, London, ON, Canada
Waddington, J. (författare)
Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
Pompili, M. (författare)
Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, SantAndrea Hospital, Sapienza University of Rome, Rome, Italy
Comparelli, A. (författare)
Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, SantAndrea Hospital, Sapienza University of Rome, Rome, Italy
Corigliano, V. (författare)
Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, SantAndrea Hospital, Sapienza University of Rome, Rome, Italy
Rancans, E. (författare)
Department of Psychiatry and Narcology, Riga Stradins University, Riga, Latvia
Navickas, A. (författare)
Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania; Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania
Hilbig, J. (författare)
Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania; Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania
Bukelskis, L. (författare)
Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania; Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania
Stevovic, L.I. (författare)
Clinical Department of Psychiatry, Clinical Centre of Montenegro, Podgorica, Montenegro; Department of Psychiatry, School of Medicine, University of Montenegro, Podgorica, Montenegro; Clinical Department of Neurology, Clinical Centre of Montenegro, Podgorica, Montenegro
Vodopic, S. (författare)
Clinical Department of Psychiatry, Clinical Centre of Montenegro, Podgorica, Montenegro; Department of Psychiatry, School of Medicine, University of Montenegro, Podgorica, Montenegro; Clinical Department of Neurology, Clinical Centre of Montenegro, Podgorica, Montenegro
Esan, O. (författare)
Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Oladele, O. (författare)
Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Osunbote, C. (författare)
Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Rybakowski, J.K. (författare)
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
Wojciak, P. (författare)
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
Domowicz, K. (författare)
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland
Figueira, M.L. (författare)
Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal
Linhares, L. (författare)
Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal
Crawford, J. (författare)
Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal
Panfil, A.-L. (författare)
University of Medicine and Pharmacy of Târgu Mures, Târgu Mures, Romania
Smirnova, D. (författare)
Department of Psychiatry, Samara Psychiatric Hospital, Inpatient Unit, Samara State Medical University, Samara, Russian Federation
Izmailova, O. (författare)
Department of Psychiatry, Samara Psychiatric Hospital, Inpatient Unit, Samara State Medical University, Samara, Russian Federation
Lecic-Tosevski, D. (författare)
Institute of Mental Health, Belgrade, Serbia; Serbian Academy of Sciences and Arts, Belgrade, Serbia
Temmingh, H. (författare)
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
Howells, F. (författare)
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
Bobes, J. (författare)
Department of Psychiatry, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain
Garcia-Portilla, M.P. (författare)
Department of Psychiatry, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain
Garciá-Alvarez, L. (författare)
Department of Psychiatry, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain
Erzin, G. (författare)
Psychiatry Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
Karada, H. (författare)
Psychiatry Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
De, Sousa A. (författare)
Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Mumbai, India
Bendre, A. (författare)
Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Mumbai, India
Hoschl, C. (författare)
National Institute of Mental Health, Klecany, Czech Republic
Bredicean, C. (författare)
University of Medicine, Pharmacy of Timisoara, Timisoara, Romania
Papava, I. (författare)
University of Medicine, Pharmacy of Timisoara, Timisoara, Romania
Vukovic, O. (författare)
Institute of Mental Health, School of Medicine, University of Belgrade, Belgrade, Serbia
Pejuskovic, B. (författare)
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Russell, V. (författare)
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Athanasiadis, L. (författare)
1st Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
Konsta, A. (författare)
1st Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
Stein, D. (författare)
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
Berk, M. (författare)
IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia; Orygen, National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia; Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia
Dean, O. (författare)
IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia; Orygen, National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia; Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia
Tandon, R. (författare)
Department of Psychiatry, University of Florida, Gainesville, FL, United States
Kasper, S. (författare)
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
De, Hert M. (författare)
University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium; Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium; Antwerp Health Law and Ethics Chair, AHLEC University, Antwerpen, Belgium
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 (creator_code:org_t)
Cambridge University Press, 2020
2020
Engelska.
Ingår i: CNS Spectrums. - : Cambridge University Press. - 1092-8529 .- 2165-6509.
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background.The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model.Methods.Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed.Results.The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage.Conclusions.The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct “cores” of schizophrenia, the “Positive” and the “Negative,” while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

long-term course; model; outcome; Schizophrenia; staging

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