Alteration of Neuropeptides in the Lung Tissue Correlates Brain Death-Induced Neurogenic Edema

doi:10.1016/j.healun.2009.04.008

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Barklin, Anne (författare)

Alteration of Neuropeptides in the Lung Tissue Correlates Brain Death-Induced Neurogenic Edema

Artikel/kapitelEngelska2009

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:liu-20166
10.1016/j.healun.2009.04.008doi
19560702pmid
urn:nbn:se:uu:diva-114160urn
urn:nbn:se:liu:diva-20166urn

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SwePubSwePub

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Ämneskategori:art swepub-publicationtype
Ämneskategori:ref swepub-contenttype

Anmärkningar

Background: increased intracranial pressure induces neurogenic pulmonary edema (NPE), potentially explaining why only lungs from less than 20% of brain dead organ donors can be used for transplantation. This study investigated the underlying mechanisms of NPE, focusing on neuropeptides, which potently induce vasoconstriction, vasodilatation, and neurogenic inflammation. Methods: Brain death was induced in 10 pigs by increasing the intracranial pressure. Eight additional pigs served as controls. Neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP), and substance P were analyzed in plasma, bronchoalveolar lavage (BAL) fluid, and homogenized lung tissue 6 hours after brain death. Pulmonary oxygen exchange was estimated using partial pressure of arterial oxygen (Pao(2))/fraction of inspired oxygen (FIO2), and pulmonary edema by wet/dry weight ratio. Results: Brain death induced a decrease in PaO2/FIO2 (P less than 0.001) and increased the wet/dry weight of both apical (p = 0.01) and basal lobes (p = 0.03). NPY and CGRP concentrations were higher in the BAL fluid of brain-dead animals compared with controls (p = 0.02 and p = 0.02) and were positively correlated with the wet/dry weight ratio. NPY content in lung tissue was lower in brain-dead animals compared with controls (p = 0.04) and was negatively correlated with the wet/dry weight ratio. There were no differences in substance P concentrations between the groups. Conclusion: NPY was released from the lung tissue of brain-dead pigs, and its concentration was related to the extent of pulmonary edema. NPY may be one of several crucial mediators of neurogenic pulmonary edema, raising the possibility of treatment with NPY-antagonists to increase the number of available lung donors.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP hsv//swe
MEDICAL AND HEALTH SCIENCES hsv//eng
MEDICINE
MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

Theodorsson, Elvar(SwePub:) (författare)
Tyvold, Stig S.(SwePub:) (författare)
Larsson, Anders,Uppsala universitet, Anestesiologi och intensivvård(SwePub:) (författare)
Granfeldt, Asger(SwePub:) (författare)
Sloth, Erik(SwePub:) (författare)
Tonnesen, Else(SwePub:) (författare)
Uppsala universitet.Medicinska och farmaceutiska vetenskapsområdet.Medicinska fakulteten.Institutionen för kirurgiska vetenskaper.Anestesiologi och intensivvård.(SwePub:uu)1345
Linköpings universitet.Institutionen för klinisk och experimentell medicin.Klinisk kemi.(SwePub:liu)2251
Linköpings universitet.Hälsouniversitetet.(SwePub:liu)1800
Östergötlands Läns Landsting.Laboratoriemedicinskt centrum.Klinisk kemi.(SwePub:liu)4234