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Sökning: onr:"swepub:oai:DiVA.org:liu-25002" > Microsatellite inst...

Microsatellite instability and MBD4 mutation in unselected colorectal cancer

Evertsson, Sofia, 1972- (författare)
Linköpings universitet, Onkologi, Linköpings universitet, Hälsouniversitetet
Wallin, Åsa, 1976- (författare)
Linköpings universitet, Onkologi, Linköpings universitet, Hälsouniversitetet
Arbman, Gunnar, (författare)
Östergötlands Läns Landsting, Kirurgiska kliniken ViN
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Rütten, Sabine, (författare)
Linköpings universitet, Onkologi, Linköpings universitet, Hälsouniversitetet
Emterling, Anna, (författare)
Linköpings universitet, Onkologi, Linköpings universitet, Hälsouniversitetet
Zhang, Hong, 1957- (författare)
Linköpings universitet, Dermatologi, Linköpings universitet, Hälsouniversitetet
Sun, Xiao-Feng, 1959- (författare)
Linköpings universitet, Onkologi, Linköpings universitet, Hälsouniversitetet
visa färre...
2003
Engelska.
Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 23:4, s. 3569-3574
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p><strong>BACKGROUND</strong>: We investigated the prognostic significance of microsatellite instability (MSI) and the association with clinicopathological factors in colorectal cancer, and further identified MBD4 mutations and their clinicopathological significance.</p><p><strong>PATIENTS AND METHODS</strong>: MSI was analyzed in 201 colorectal cancers. Sequencing analysis of MBD4 was performed in 26 MSI and 28 microsatellite stable (MSS) tumors.</p><p><strong>RESULTS</strong>: Twenty-seven tumors (13.4%) were MSI but did not correlate with improved survival. MSI was significantly correlated with proximal colon tumors (p &lt; 0.001), poor differentiation or mucinous type (p = 0.005) and multiple tumors (p = 0.04). MBD4 mutations were found in 15% MSI but not in MSS tumors. The mutated cases showed female overrepresentation, proximal site and poorly-differentiated/mucinous type.</p><p><strong>CONCLUSION</strong>: MSI was not correlated with survival, but shared other features associated with MSI in colorectal cancer as demonstrated by others. The clinicopathological variables associated with the MBD4 mutations were probably the reflection of MSI features.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

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MEDICINE
MEDICIN

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