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IgA endomysium anti...
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Grodzinsky, Ewa,1958-Linköpings universitet,Östergötlands Läns Landsting,Forsknings- och utvecklingsenheten för Närsjukvården i Östergötland,Hälsouniversitetet
(författare)
IgA endomysium antibodies : an early predictor for celiac disease in children without villous atrophy
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
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Wiley,2008
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-42701
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-42701URI
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https://doi.org/10.1111/j.1651-2227.2008.00881.xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Aim: To evaluate possible differences between children with anti-endomysium antibodies (EMA) positivity and normal small bowel mucosa and children with positive EMA and an enteropathy diagnosed as celiac disease (CD).Methods: Children with suspected CD and positive EMA (≥1/10) undergoing small bowel biopsy during 1996 to 2002, were investigated (n = 133). Data registered were: year and month of birth, timing of the first biopsy, sex, heredity for CD, dermatitis herpetiformis and diabetes mellitus and outcome of the anti-gliadin antibody test (AGA). The case group, with EMA positivity and normal histology (n = 39; 59% female, mean age at the first biopsy 7.3 years, range 1.4–16), was compared with the disease control group, with positive EMA and a biopsy suggestive and further on diagnosed as CD (n = 94; 56% female; mean age 7.6 years at the first biopsy, range 0.70–17).Results: AGA positivity and heredity for CD were found to predict the outcome of a pathological jejunal mucosa. Nineteen of the 39 children in the case group were rebiopsied of whom 11 had developed an enteropathy during a follow-up period of 2–7 years (median 4.5 years).Conclusions: EMA positivity in the absence of small bowel enteropathy could be a very early predictor for later overt CD, and necessitates further follow-up, especially if the child is AGA positive and there is a family history of CD.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Fälth-Magnusson, Karin,1949-Linköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)karfa12
(författare)
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Högberg, Lotta,1960-Norrköping Hospital, Norrköping, Sweden(Swepub:liu)lotho28
(författare)
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Jansson, GunnarMotala Hospital, Motala, Sweden
(författare)
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Laurin, Pia,1969-Linköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)piala63
(författare)
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Stenhammar, Lars,1939-Linköpings universitet,Pediatrik,Hälsouniversitetet(Swepub:liu)larst66
(författare)
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Östergötlands Läns LandstingForsknings- och utvecklingsenheten för Närsjukvården i Östergötland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Acta Paediatrica: Wiley97:7, s. 972-9760803-52531651-2227
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