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Sökning: onr:"swepub:oai:DiVA.org:liu-43636" > Overexpression of I...

Overexpression of Id-1 protein is a marker in colorectal cancer progression

Zhao, Zeng-Ren, (författare)
Department of General Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China
Zhang, Zhi-Yong, (författare)
Department of Oncology, Institute of Biomedicine and Surgery, Linköping University, Linköping, Sweden / Department of Pathology, Tangshan Gongren Hospital, Tangshan, P.R. China
Zhang, Hong, (författare)
Department of Dermatology, Institute of Biomedicine and Surgery, Linköping University, Linköping, Sweden
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Jiang, Li, (författare)
Department of Pathology, Tangshan Gongren Hospital, Tangshan, P.R. China
Wang, Ming-Wei, (författare)
Laboratory Centre, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China
Sun, Xiao-Feng, (författare)
Department of Oncology, Institute of Biomedicine and Surgery, Linköping University, Linköping, Sweden
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Linköpings universitet Hälsouniversitetet. (creator_code:org_t)
Linköpings universitet Institutionen för klinisk och experimentell medicin. Onkologi. (creator_code:org_t)
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Linköpings universitet Institutionen för klinisk och experimentell medicin. Dermatologi och venerologi. (creator_code:org_t)
Östergötlands Läns Landsting Kirurgi- och onkologicentrum. Onkologiska kliniken US. (creator_code:org_t)
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2008
Engelska.
Ingår i: Oncology Reports. - 1021-335X. ; 19:2, s. 419-424
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The inhibitor of differentiation/DNA binding 1 (Id-1), a negative regulator of basic helix-loop-helix transcription factors, plays an important role in the regulation of cell proliferation and differentiation. We examined the Id-1 expression by immunohistochemistry in 9 adenomas, 79 primary colorectal adenocarcinomas matched with 40 adjacent normal mucosa specimens and its relationship with clinicopathological factors. The Id-1 expression was increased in the carcinoma compared to the adjacent normal mucosa either in the unmatched and matched samples or to the adenoma. There was no significant difference in the Id-1 expression between normal mucosa and adenoma. The Id-1 expression of carcinoma was increased from Dukes' stages A to B, to C and to D. The cases with lymph node metastasis had a higher rate of a stronger Id-1 expression than those without lymph node metastasis. In conclusion, Id-1 overexpression plays an important role in colorectal cancer progression.

Ämnesord

NATURVETENSKAP  -- Biologiska vetenskaper -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

Nyckelord

NATURAL SCIENCES Biology Cell and molecular biology
NATURVETENSKAP Biologi Cell- och molekylärbiologi
MEDICINE
MEDICIN

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