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Sökning: onr:"swepub:oai:DiVA.org:liu-66138" > A genome-wide analy...

A genome-wide analysis of population structure in the Finnish Saami with implications for genetic association studies

Huyghe, Jeroen R (författare)
University of Antwerp
Fransen, Erik (författare)
University of Antwerp,Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUA Statistics Center, University of Antwerp, Antwerp, Belgium
Hannula, Samuli (författare)
University of Oulu,Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
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Van Laer, Lut (författare)
University of Antwerp,Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Van Eyken, Els (författare)
University of Antwerp,Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Mäki-Torkko, Elina (författare)
Örebro universitet,Linköpings universitet,Teknisk audiologi,Hälsouniversitetet,Institutionen för medicinska vetenskaper,Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Oulu, Finland; Department of Clinical and Experimental Medicine/Technical Audiology, Linköping University, Linköping, Sweden
Aikio, Pekka (författare)
University of Oulu,Thule Institute, University of Oulu, Oulu, Finland
Sorri, Martti (författare)
University of Oulu,Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
Huentelman, Matthew J (författare)
Translat Genom Research Institute, Phoenix
Van Camp, Guy (författare)
University of Antwerp,Department of Medical Genetics, University of Antwerp,Antwerp, Belgium
Huentelman, Matthew J. (författare)
Neurogenomics Division, Translational Genomics Research Institute, Phoenix AZ, USA
Huyghe, Jeroen R. (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
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 (creator_code:org_t)
Nature Publishing Group, 2011
2011
Engelska.
Ingår i: EUROPEAN JOURNAL OF HUMAN GENETICS. - : Nature Publishing Group. - 1018-4813 .- 1476-5438. ; 19:3, s. 347-352
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The understanding of patterns of genetic variation within and among human populations is a prerequisite for successful genetic association mapping studies of complex diseases and traits. Some populations are more favorable for association mapping studies than others. The Saami from northern Scandinavia and the Kola Peninsula represent a population isolate that, among European populations, has been less extensively sampled, despite some early interest for association mapping studies. In this paper, we report the results of a first genome-wide SNP-based study of genetic population structure in the Finnish Saami. Using data from the HapMap and the human genome diversity project (HGDP-CEPH) and recently developed statistical methods, we studied individual genetic ancestry. We quantified genetic differentiation between the Saami population and the HGDP-CEPH populations by calculating pair-wise F-ST statistics and by characterizing identity-by-state sharing for pair-wise population comparisons. This study affirms an east Asian contribution to the predominantly European-derived Saami gene pool. Using model-based individual ancestry analysis, the median estimated percentage of the genome with east Asian ancestry was 6% (first and third quartiles: 5 and 8%, respectively). We found that genetic similarity between population pairs roughly correlated with geographic distance. Among the European HGDP-CEPH populations, F-ST was smallest for the comparison with the Russians (F-ST=0.0098), and estimates for the other population comparisons ranged from 0.0129 to 0.0263. Our analysis also revealed fine-scale substructure within the Finnish Saami and warns against the confounding effects of both hidden population structure and undocumented relatedness in genetic association studies of isolated populations.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Nyckelord

Saami
genetic association studies
population structure
population isolates
MEDICINE
MEDICIN

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