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Sökning: onr:"swepub:oai:DiVA.org:liu-74185" > Up-regulation of sm...

Up-regulation of small intestinal interleukin-17 immunity in untreated coeliac disease but not in potential coeliac disease or in type 1 diabetes

Lahdenperä, Anna, (författare)
Linköpings universitet, Pediatrik, Linköpings universitet, Hälsouniversitetet
Hölttä, V, (författare)
National Institute for Health and Welfare, Finland
Ruohtula, T, (författare)
National Institute for Health and Welfare, Finland
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Salo, H M, (författare)
National Institute for Health and Welfare, Finland
Orivuori, L, (författare)
National Institute for Health and Welfare, Finland
Westerholm-Ormio, M, (författare)
Hospital for Children and Adolescents, University of Helsinki,
Savilahti, E, (författare)
Hospital for Children and Adolescents, University of Helsinki,
Fälth-Magnusson, Karin, (författare)
Linköpings universitet, Pediatrik, Linköpings universitet, Hälsouniversitetet, Östergötlands Läns Landsting, Barn- och ungdomskliniken i Linköping
Högberg, Lotta, (författare)
Linköpings universitet, Pediatrik, Linköpings universitet, Hälsouniversitetet, Östergötlands Läns Landsting, Barn- och ungdomskliniken i Norrköping
Ludvigsson, Johnny, (författare)
Linköpings universitet, Pediatrik, Linköpings universitet, Hälsouniversitetet, Östergötlands Läns Landsting, Barn- och ungdomskliniken i Linköping
Vaarala, O, (författare)
National Institute for Health and Welfare, Finland
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2012
Engelska.
Ingår i: Clinical and Experimental Immunology. - John Wiley & Sons. - 0009-9104 .- 1365-2249. ; 167:2, s. 226-234
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p>Up-regulation of interleukin (IL)-17 in small intestinal mucosa has been reported in coeliac disease (CD) and in peripheral blood in type 1 diabetes (T1D). We explored mucosal IL-17 immunity in different stages of CD, including transglutaminase antibody (TGA)-positive children with potential CD, children with untreated and gluten-free diet-treated CD and in children with T1D. Immunohistochemistry was used for identification of IL-17 and forkhead box protein 3 (FoxP3)-positive cells and quantitative polymerase chain reaction (qPCR) for IL-17, FoxP3, retinoic acid-related orphan receptor (ROR)c and interferon (IFN)-γ transcripts. IL-1β, IL-6 and IL-17 were studied in supernatants from biopsy cultures. Expression of the apoptotic markers BAX and bcl-2 was evaluated in IL-17-stimulated CaCo-2 cells. The mucosal expression of IL-17 and FoxP3 transcripts were elevated in individuals with untreated CD when compared with the TGA-negative reference children, children with potential CD or gluten-free diet-treated children with CD (P andlt; 0·005 for all IL-17 comparisons and P andlt; 0·01 for all FoxP3 comparisons). The numbers of IL-17-positive cells were higher in lamina propria in children with CD than in children with T1D (P andlt; 0·05). In biopsy specimens from patients with untreated CD, enhanced spontaneous secretion of IL-1β, IL-6 and IL-17 was seen. Activation of anti-apoptotic bcl-2 in IL-17-treated CaCo-2 epithelial cells suggests that IL-17 might be involved in mucosal protection. Up-regulation of IL-17 could, however, serve as a biomarker for the development of villous atrophy and active CD.</p>

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MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

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MEDICINE
MEDICIN

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