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Histopathological Classification of Pseudomyxoma Peritonei and the Prognostic Importance of PINCH Protein

Andreasson, Hakan, (författare)
Uppsala University
Wanders, Alkwin, (författare)
Uppsala University
Sun, Xiao-Feng, (författare)
Linköpings universitet, Onkologi, Linköpings universitet, Hälsouniversitetet, Östergötlands Läns Landsting, Onkologiska kliniken US
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Willen, Roger, (författare)
Uppsala University
Graf, Wilhelm, (författare)
Uppsala University
Nygren, Peter, (författare)
Uppsala University
Glimelius, Bengt, (författare)
Uppsala University
Zhang, Zhi-Yong, (författare)
Tangshan Gongren Hospital
Mahteme, Haile, (författare)
Uppsala University
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2012
Engelska.
Ingår i: Anticancer Research. - International Institute of Anticancer Research (IIAR). - 0250-7005 .- 1791-7530. ; 32:4, s. 1443-1448
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p>Aim: The aims of this study were i) to assess a new and more detailed histopathological classification and to analyze concordance between pathologists in the histopathological classification of pseudomyxoma peritonei (PMP); ii) to analyze the expression in the stroma of the particularly interesting new cysteine-histidine (PINCH) protein and its prognostic importance in PMP. Materials and Methods: Surgical specimens from 81 patients, classified according to the Ronnett et al histopathological classification were compared to a new system with four groups ranging from indolent to aggressive growth patterns. PINCH protein expression was analyzed and was related to clinical variables. Results: The new four-group classification provided better prognostic information than the classification according to Ronnett et al. (p=0.04). Expression of the PINCH protein in the stroma was found in 83% of the cases and was associated with high tumor burden (p=0.002) and a poor prognosis (p=0.04). Conclusion: The proposed new PMP classification system may provide additional prognostic information. PINCH protein is expressed in PMP and has prognostic information.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

Nyckelord

Pseudomyxoma peritonei
histopathology
PINCH
protein expression
cytokeratin 7
Ki-67
MEDICINE
MEDICIN

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