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Redistribution of intracellular Ca2+ stores during phagocytosis in human neutrophils

Stendahl, Olle (författare)
Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
Krause, Karl-Heins (författare)
Division of Infectious Diseases, Hôpital Cantonal Universitaire, Switzerland
Krischer, Joachim (författare)
Department of Morphology, Centre Medical Universitaire, Switzerland
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Jerström, Petra (författare)
Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
Theler, Jean-Marc (författare)
Clinical Biochemistry, Centre Medical Universitaire, Switzerland
Clark, Rober A. (författare)
Department of Medicine, VA Medical Center and University of Iowa, USA
Carpentier, Jean-Louis (författare)
Department of Morphology, Centre Medical Universitaire, Switzerland
Lew, Daniel P. (författare)
Division of Infectious Diseases, Hôpital Cantonal Universitaire, Switzerland
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 (creator_code:org_t)
1994
1994
Engelska.
Ingår i: Science. - 0036-8075 .- 1095-9203. ; 265:5177, s. 1439-1441
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Subcellular gradients of cytosolic free Ca2+ concentration, [Ca2+]i, are thought to be critical for the localization of functional responses within a cell. A potential but previously unexplored mechanism for the generation of gradients of [Ca2+]i is the accumulation of Ca2+ stores at the site of Ca2+ action. The distribution of the Ca2+ store markers Ca(2+)-dependent adenosine triphosphatase and calreticulin was investigated in resting and phagocytosing human neutrophils. Both proteins showed an evenly distributed fine granular pattern in nonphagocytosing cells, but became markedly concentrated in the filamentous actin-rich cytoplasmic area around the ingested particle during phagocytosis. This redistribution began at early stages of phagocytosis and did not depend on an increase in [Ca2+]i. Thus, accumulation of Ca2+ stores in a restricted area of the cell may contribute to the generation of localized increases in [Ca2+]i.

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MEDICIN

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