Harvard University, MA USA,Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA.
Cerhan, James R. (författare)
Mayo Clin, MN USA,Mayo Clin, Coll Med, Dept Hlth Sci Res, Rochester, MN USA.
Gaudet, Mia M. (författare)
Amer Cancer Soc, GA USA,Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
Giles, Graham G. (författare)
Cancer Council Victoria, Australia,Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic, Australia.;Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.
Goodman, Gary (författare)
Fred Hutchinson Cancer Research Centre, WA USA,Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.
Hakansson, Niclas (författare)
Karolinska Institute, Sweden,Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, S-10401 Stockholm, Sweden.
Hankinson, Susan E. (författare)
Harvard University, MA USA,Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Univ Massachussetts, Div Biostat & Epidemiol, Amherst, MA USA.
Helzlsouer, Kathy (författare)
St Johns Mercy Medical Centre, MD USA,St Johns Mercy Med Ctr, Weinberg Ctr Womens Hlth & Med, Prevent & Res Ctr, Baltimore, MD USA.;Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
Horn-Ross, Pamela L. (författare)
Cancer Prevent Institute Calif, CA USA,Canc Prevent Inst Calif, Fremont, CA USA.
Inoue, Manami (författare)
National Cancer Centre, Japan,Natl Canc Ctr, Res Ctr Canc Prevent & Screening, Epidemiol & Prevent Div, Tokyo 104, Japan.
Krogh, Vittorio (författare)
Fdn IRCCS Ist Nazl Tumori Milano, Italy,Fdn IRCCS Ist Nazl Tumori Milano, Nutr Epidemiol Unit, Milan, Italy.
Estrogen receptornegative (ER) breast cancer has few known or modifiable risk factors. Because ER tumors account for only 15% to 20% of breast cancers, large pooled analyses are necessary to evaluate precisely the suspected inverse association between fruit and vegetable intake and risk of ER breast cancer. less thanbrgreater than less thanbrgreater thanAmong 993 466 women followed for 11 to 20 years in 20 cohort studies, we documented 19 869 estrogen receptor positive (ER) and 4821 ER breast cancers. We calculated study-specific multivariable relative risks (RRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression analyses and then combined them using a random-effects model. All statistical tests were two-sided. less thanbrgreater than less thanbrgreater thanTotal fruit and vegetable intake was statistically significantly inversely associated with risk of ER breast cancer but not with risk of breast cancer overall or of ER tumors. The inverse association for ER tumors was observed primarily for vegetable consumption. The pooled relative risks comparing the highest vs lowest quintile of total vegetable consumption were 0.82 (95% CI 0.74 to 0.90) for ER breast cancer and 1.04 (95% CI 0.97 to 1.11) for ER breast cancer (Pcommon-effects by ER status andlt; .001). Total fruit consumption was non-statistically significantly associated with risk of ER breast cancer (pooled multivariable RR comparing the highest vs lowest quintile 0.94, 95% CI 0.85 to 1.04). less thanbrgreater than less thanbrgreater thanWe observed no association between total fruit and vegetable intake and risk of overall breast cancer. However, vegetable consumption was inversely associated with risk of ER breast cancer in our large pooled analyses.
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)