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Effects of adjuvant...
Effects of adjuvant tamoxifen therapy on cardiac disease: results from a randomized trial with long-term follow-up
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- Rosell, Johan (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Regionalt cancercentrum
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- Nordenskjöld, Bo (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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- Bengtsson, Nils-Olof (författare)
- Umeå universitet,Onkologi,Umeå University Hospital, Sweden
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- Fornander, Tommy (författare)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Hatschek, Thomas (författare)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Lindman, Henrik (författare)
- Uppsala universitet,Enheten för onkologi,University of Uppsala Hospital, Sweden
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- Malmström, Per (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden
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- Wallgren, Arne (författare)
- Sahlgrens University Hospital, Sweden
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- Stål, Olle (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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- Carstensen, John (författare)
- Linköpings universitet,Hälsa och samhälle,Hälsouniversitetet
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(creator_code:org_t)
- 2013-03-02
- 2013
- Engelska.
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Ingår i: Breast Cancer Research and Treatment. - New York : SPRINGER, 233 SPRING ST, NEW YORK, NY 10013 USA. - 0167-6806 .- 1573-7217. ; 138:2, s. 467-473
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Tamoxifen is associated with a reduced risk of coronary heart disease (CHD). However, there are few reports on long-term effects. Using data from a large Swedish randomized trial of 5 and 2 years of adjuvant tamoxifen in women with early breast cancer, we here present results on morbidity and mortality from cardiac diseases during treatment and long-term after treatment. A total of 4,150 patients were breast cancer recurrence-free after 2 years. Data from the Swedish National Hospital Discharge Registry combined with information from the Swedish Cause of Death Registry were used to define events of disease. Hazard ratios were estimated using Cox regression. Patients assigned to 5 years in comparison with 2 years of postoperative tamoxifen experienced a reduced incidence of CHD [hazard ratio (HR), 0.83; 95 % CI 0.70-1.00], especially apparent during the active treatment period (HR 0.65; 95 % CI 0.43-1.00). The mortality from CHD was significantly reduced (HR 0.72; 95 % CI 0.53-0.97). During the active treatment, the morbidity of other heart diseases was also significantly reduced (HR 0.40; 95 % CI 0.25-0.64) but not after treatment stopped (HR 1.06; 95 % CI 0.87-1.30). Similar results were seen for both heart failure and atrial fibrillation/flutter. As compared to 2 years of therapy, 5 years of postoperative tamoxifen therapy prevents CHD as well as other heart diseases. The risk reduction is most apparent during the active treatment period, and later tends to diminish.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast cancer
- Tamoxifen
- Adjuvant treatment
- Adverse events
- Heart failure
- Coronary heart disease
- SOCIAL SCIENCES
- SAMHÄLLSVETENSKAP
- Breast cancer
- Tamoxifen
- Adjuvant treatment
- Adverse events
- Heart
- failure
- Coronary heart disease
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Rosell, Johan
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Nordenskjöld, Bo
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Bengtsson, Nils- ...
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Fornander, Tommy
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Hatschek, Thomas
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Lindman, Henrik
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visa fler...
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Malmström, Per
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Wallgren, Arne
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Stål, Olle
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Carstensen, John
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Breast Cancer Re ...
- Av lärosätet
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Linköpings universitet
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Lunds universitet
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Karolinska Institutet
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Umeå universitet
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Uppsala universitet