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Impact of Dye-Prote...
Impact of Dye-Protein Interaction and Silver Nanoparticles on Rose Bengal Photophysical Behavior and Protein Photocrosslinking
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- Simpson, Madeline J. (författare)
- University of Ottawa, ON, Canada
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- Poblete, Horacio (författare)
- Center for Bioinformatics and Molecular Simulation, Universidad de Talca, Chile
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- Griffith, May (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,University of Ottawa Eye Institute, ON, Canada
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- Alarcon, Emilio I. (författare)
- University of Ottawa, ON, Canada
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- Scaiano, Juan C. (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,University of Ottawa, ON, Canada
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(creator_code:org_t)
- 2013-08-17
- 2013
- Engelska.
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Ingår i: Photochemistry and Photobiology. - : Wiley-Blackwell. - 0031-8655 .- 1751-1097. ; 89:6, s. 1433-1441
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The role of recombinant Type-I human collagen in the free form or forming AgNP@collagen on the photophysical and photochemical behavior of rose Bengal was analyzed. The formation of dye aggregates on the protein surface was experimentally observed and corroborated by docking calculations. The formation of such aggregates is believed to change the main oxidative mechanism from Type-II (singlet oxygen) to Type-I (free radical) photosensitization. Remarkably, the presence of AgNP in the form of AgNP@collagen altered the dynamics of dye triplet deactivation, effectively preventing the dye degradation and reducing the extent of protein crosslinked. Both crosslinked rHC and AgNP@collagen were able to support fibroblasts proliferation, but only the material containing silver was resistant to S. epidermidis infection.
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- art (ämneskategori)
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