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Carriage of CTX-M t...
Carriage of CTX-M type extended spectrum beta-lactamases (ESBLs) in gulls across Europe
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- Stedt, Johan (författare)
- Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Linnéuniversitetet, Institutionen för biologi och miljö (BOM),Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, Sch Nat Sci, S-39182 Kalmar, Sweden.
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- Bonnedahl, Jonas (författare)
- Uppsala universitet,Klinisk mikrobiologi och infektionsmedicin,Kalmar Cty Hosp, Dept Infect Dis, S-39185 Kalmar, Sweden.
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- Hernandez, Jorge (författare)
- Uppsala universitet,Klinisk mikrobiologi och infektionsmedicin
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- Waldenström, Jonas (författare)
- Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Linnéuniversitetet, Institutionen för biologi och miljö (BOM),Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, Sch Nat Sci, S-39182 Kalmar, Sweden.
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- McMahon, Barry J. (författare)
- University College Dublin, UK,Univ Coll Dublin, Sch Agri Culture & Food Sci, Dublin 4, Ireland.
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- Tolf, Conny (författare)
- Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Linnéuniversitetet, Institutionen för biologi och miljö (BOM),Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, Sch Nat Sci, S-39182 Kalmar, Sweden.
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- Olsen, Björn (författare)
- Uppsala universitet,Klinisk mikrobiologi och infektionsmedicin,Institutionen för medicinsk biokemi och mikrobiologi,Infektionssjukdomar
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- Drobni, Mirva (författare)
- Uppsala universitet,Klinisk mikrobiologi och infektionsmedicin,Ostersund Hosp, Dept Lab Med Clin Microbiol, S-83183 Ostersund, Sweden.
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(creator_code:org_t)
- 2015-11-02
- 2015
- Engelska.
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Ingår i: Acta Veterinaria Scandinavica. - : Springer Science and Business Media LLC. - 0044-605X .- 1751-0147. ; 57
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https://doi.org/10.1...
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https://actavetscand...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Extended spectrum beta-lactamases (ESBLs), a group of enzymes conferring resistance to third generation cephalosporins have rapidly increased in Enterobacteriacae and pose a major challenge to human health care. Resistant isolates are common in domestic animals and clinical settings, but prevalence and genotype distribution varies on a geographical scale. Although ESBL genes are frequently detected in bacteria isolated from wildlife samples, ESBL dissemination of resistant bacteria to the environment is largely unknown. To address this, we used three closely related gull species as a model system and collected more than 3000 faecal samples during breeding times in nine European countries. Samples were screened for ESBL-producing bacteria, which were characterized to the level of ESBL genotype groups (SHV, TEM), or specific genotypes (CTX-M). Results: ESBL-producing bacteria were frequently detected in gulls (906 of 3158 samples, 28.7 %), with significant variation in prevalence rates between countries. Highest levels were found in Spain (74.8 %), The Netherlands (37.8 %) and England (27.1 %). Denmark and Poland represented the other extreme with no, or very few positive samples. Genotyping of CTX-M isolates identified 13 different variants, with bla(CTX-M-1) and bla(CTX-M-14) as the most frequently detected. In samples from England, Spain and Portugal, blaCTX-M-14 dominated, while in the rest of the sampled countries blaCTX-M-1 (except Sweden where bla(CTX-M-15) was dominant) was the most frequently detected genotype, a pattern similar to what is known from studies of human materials. Conclusions: CTX-M type ESBLs are common in the faecal microbiota from gulls across Europe. The gull ESBL genotype distribution was in large similar to published datasets from human and food-production animals in Europe. The data suggests that the environmental dissemination of ESBL is high from anthropogenic sources, and widespread occurrence of resistant bacteria in common migratory bird species utilizing urban and agricultural areas suggests that antibiotic resistance genes may also be spread through birds.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- ESBL
- CTX-M
- Wildlife
- Birds
- Gulls
- Antibiotic resistance
- E. coli
- Europe
- Zoonotisk ekologi
- Zoonotic Ecology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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