SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:lnu-70244"
 

Sökning: onr:"swepub:oai:DiVA.org:lnu-70244" > Serum uric acid lev...

Serum uric acid levels are associated with cardiovascular risk score : A post hoc analysis of the EURIKA study

Borghi, Claudio (författare)
Univ Bologna, Italy
Rodriguez-Artalejo, Fernando (författare)
Univ Autonoma Madrid, Spain;Inst Salud Carlos III, Spain;IMDEA, Spain;CEI UAM CSIC, Spain
De Backer, Guy (författare)
Univ Ghent, Belgium
visa fler...
Dallongeville, Jean (författare)
Univ Lille Nord France, France
Medina, Jesus (författare)
AstraZeneca, Spain
Nuevo, Javier (författare)
AstraZeneca, Spain
Guallar, Eliseo (författare)
Johns Hopkins Bloomberg Sch Publ Hlth, USA
Perk, Joep, 1945- (författare)
Linnéuniversitetet,Institutionen för hälso- och vårdvetenskap (HV)
Banegas, Jose R. (författare)
Univ Autonoma Madrid, Spain;Inst Salud Carlos III, Spain
Tubach, Florence (författare)
Hop La Pitie Salpetriere, France;INSERM, France;Sorbonne Univ, France
Roy, Carine (författare)
Hop Bichat Claude Bernard, France
Halcox, Julian P. (författare)
Swansea Univ, UK
visa färre...
 (creator_code:org_t)
Elsevier, 2018
2018
Engelska.
Ingår i: International Journal of Cardiology. - : Elsevier. - 0167-5273 .- 1874-1754. ; 253, s. 167-173
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Reports are conflicting on whether serum uric acid (sUA) levels are independently associated with increased cardiovascular (CV) death risk. Methods: This post hoc analysis assessed the relationship between sUA levels and CV death risk score in 7531 patients from the cross-sectional, multinational EURIKA study (NCT00882336). Patients had at least one CV risk factor but no clinical CV disease. Ten-year risk of CV death was estimated using SCORE-HDL and SCORE algorithms, categorized as low (<1%), intermediate (1% to <5%), high (>5% to <10%) or very high (>10%). Results: Mean serum sUA levels increased significantly with increasing CV death risk category in the overall population and in subgroups stratified by diuretics use or renal function (all P < 0.0001). Multivariate ordinal logistic regression analyses, adjusted for factors significantly associated with CV death risk in univariate analyses (study country, body mass index, number of CV risk factors and comorbidities, use of lipid lowering therapies, antihypertensives and antidiabetics), showed a significant association between sUA levels and SCORE-HDL category in the overall population (OR: 1.39 [95% CI: 1.34-1.44]) and all subgroups (using diuretics: 1.32 [1.24-1.40]; not using diuretics: 1.46 [1.39-1.53]; estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m(2): 1.30 [1.22-1.38]; eGFR >= 60 ml/min/1.73 m(2): 1.44 [1.38-1.51]; all P < 0.0001). Similar results were obtained when using SCORE. Conclusions: Higher sUA levels are associated with progressively higher 10-year CV death risk score in patients with at least one CV risk factor but no CV disease. (c) 2017 Elsevier B.V. All rights reserved.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nursing (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper -- Omvårdnad (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Kardiologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)

Nyckelord

Serum uric acid
Cardiovascular risk
European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA)
Systematic COronary Risk Evaluation (SCORE)
Systematic COronary Risk Evaluation algorithm including high-density lipoprotein cholesterol (SCORE-HDL)
Health and Caring Sciences
Hälsovetenskap

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy