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Clinical trial :
Clinical trial : colectomy after rescue therapy in ulcerative colitis-3-year follow-up of the Swedish-Danish controlled infliximab study
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- Gustavsson, Anders (författare)
- Örebro universitet,Hälsoakademin,Örebro University Hospital, Örebro, Sweden
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- Järnerot, G. (författare)
- School of Health and Medical Science, Örebro University, Örebro, Sweden; Örebro University Hospital, Örebro, Sweden
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- Hertervig, Erik (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital, Sweden
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- Friis-Liby, I. (författare)
- Dept Med, Div Gastroenterol, Sahlgrens Univ Hosp, Gothenburg, Sweden,Sahlgrenska University Hospital, Göteborg, Sweden
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- Blomquist, L. (författare)
- Dept Gastroenterol & Hepatol, Karolinska Univ Hosp, Stockholm, Sweden,Karolinska University Hospital, Sweden
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- Karlén, P. (författare)
- Karolinska Institutet,Södersjukhuset, Stockholm, Sweden
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- Grännö, C. (författare)
- Dept Med, Div Gastroenterol, Ryhov Hosp, Jönköping, Sweden,Ryhov Hospital, Jönköping
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- Vilien, M. (författare)
- Div Gastroenterol, Hillerød Hosp, Hillerød, Denmark,Hilleroed Hospital, Denmark
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- Ström, Magnus (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
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- Verbaan, Hans (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Malmö General University Hospital, Sweden
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- Hellström, Per M., 1954- (författare)
- Dept Gastroenterol & Hepatol, Karolinska Univ Hosp, Stockholm, Sweden,Karolinska University Hospital, Sweden
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- Magnuson, A. (författare)
- Örebro University Hospital, Örebro, Sweden
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- Halfvarson, Jonas (författare)
- Örebro universitet,Hälsoakademin,Örebro University Hospital, Örebro, Sweden
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- Tysk, Curt (författare)
- Örebro universitet,Hälsoakademin,Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2010-08-18
- 2010
- Engelska.
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Ingår i: Alimentary Pharmacology and Therapeutics. - : Wiley. - 0269-2813 .- 1365-2036. ; 32:8, s. 984-989
- Relaterad länk:
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https://onlinelibrar...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background The long-term efficacy of infliximab as rescue therapy in steroid-refractory ulcerative colitis is not well described. Aim To examine the long-term efficacy of infliximab as a rescue therapy through a 3-year follow-up of a previous placebo-controlled trial of infliximab in acute steroid-refractory ulcerative colitis. Method In the original study, 45 patients were randomized to a single infusion of infliximab 5 mg/kg or placebo, and at 3 months, 7/24 patients given infliximab were operated vs. 14/21 patients given placebo. Three years or later, patients were asked to participate in a clinical follow-up. Results Another seven patients underwent colectomy during follow-up: five in the infliximab group and two in the placebo group. After 3 years, a total of 12/24 (50%) patients given infliximab and 16/21 (76%) given placebo (P = 0.012) had a colectomy. None of eight patients in endoscopic remission at 3 months later had a colectomy compared with 7/14 (50%) patients who were not in remission (P = 0.02). There was no mortality. Conclusion The benefit of rescue therapy with infliximab in steroid-refractory acute ulcerative colitis remained after 3 years. The main advantage of infliximab treatment occurred during the first 3 months, whereas subsequent colectomy rates were similar in the two groups. Mucosal healing at 3 months influenced later risk of colectomy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
- Medicine
- Medicin
- Medical Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gustavsson, Ande ...
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Järnerot, G.
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Hertervig, Erik
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Friis-Liby, I.
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Blomquist, L.
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Karlén, P.
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Grännö, C.
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Vilien, M.
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Ström, Magnus
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Verbaan, Hans
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Hellström, Per M ...
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Magnuson, A.
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Halfvarson, Jona ...
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Tysk, Curt
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Alimentary Pharm ...
- Av lärosätet
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Örebro universitet
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Lunds universitet
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Uppsala universitet
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Karolinska Institutet
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Linköpings universitet