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Plasmodium falcipar...
Plasmodium falciparum infection patterns since birth and risk of severe malaria : a nested case-control study in children on the coast of Kenya
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- Lundblom, Klara (författare)
- Karolinska Institutet
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- Murungi, Linda (författare)
- Centre for Geographical Medicine Research (Coast), Kilifi, Kenya
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- Nyaga, Victoria (författare)
- Centre for Geographical Medicine Research (Coast), Kilifi, Kenya
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- Olsson, Daniel (författare)
- Karolinska Institutet
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- Rono, Josea (författare)
- Karolinska Institute, Stockholm, Sweden; Geographical Medicine Research (Coast), Kilifi, Kenya
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- Osier, Faith (författare)
- Centre for Geographical Medicine Research (Coast), Kilifi, Kenya
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- Ogada, Edna (författare)
- Centre for Geographical Medicine Research (Coast), Kilifi, Kenya
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- Montgomery, Scott (författare)
- Karolinska Institutet,Örebro universitet,Hälsoakademin,Region Örebro County, Örebro, Sweden
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- Scott, J. Anthony G. (författare)
- Churchill Hospital, University of Oxford, Oxford, United Kingdom
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- Marsh, Kevin (författare)
- Centre for Geographical Medicine Research (Coast), Kilifi, Kenya
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- Färnert, Anna (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2013-02-13
- 2013
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:2, s. e56032-
- Relaterad länk:
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https://doi.org/10.1...
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Children in malaria endemic areas acquire immunity to severe malaria faster than to mild malaria. Only a minority of children suffers from severe malaria and it is not known what determines this. The aim of this study was to establish how P. falciparum infections during the first years of life affect the risk of severe malaria. A matched case-control study was nested within a large birth cohort set up to study the immunoepidemiology of pneumococci on the Kenyan coast. Infection patterns in three-monthly blood samples in cohort children admitted to hospital with severe malaria were compared to controls matched on age, residential location and time of sampling. P. falciparum detected at least once from birth conferred an increased risk of severe malaria and particularly if multiclonal infections, as characterized by genotyping of a polymorphic antigen gene, were ever detected. The results show for the first time that children with severe malaria have more infections early in life compared to community controls. These findings provide important insights on the immunity to severe disease, knowledge essential for the development of a vaccine against severe malaria.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Medicine
- Medicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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PLOS ONE
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Till lärosätets databas
- Av författaren/redakt...
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Lundblom, Klara
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Murungi, Linda
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Nyaga, Victoria
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Olsson, Daniel
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Rono, Josea
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Osier, Faith
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visa fler...
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Ogada, Edna
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Montgomery, Scot ...
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Scott, J. Anthon ...
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Marsh, Kevin
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Färnert, Anna
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Immunologi inom ...
- Artiklar i publikationen
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PLOS ONE
- Av lärosätet
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Örebro universitet
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Karolinska Institutet