SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:oru-41456"
 

Sökning: onr:"swepub:oai:DiVA.org:oru-41456" > Prospective study o...

Prospective study of Trichomonas vaginalis infection and prostate cancer incidence and mortality : Physicians' Health Study

Stark, Jennifer R. (författare)
Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA
Judson, Gregory (författare)
Department of Epidemiology, Harvard School of Public Health, Boston, USA
Alderete, John F. (författare)
School of Molecular Biosciences, Washington State University, Pullman, USA
visa fler...
Mundodi, Vasanthakrishna (författare)
Molecular Biosciences, Washington State University, Pullman, USA
Kucknoor, Ashwini S. (författare)
Molecular Biosciences, Washington State University, Pullman, USA
Giovannucci, Edward L. (författare)
Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Nutrition, School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA
Platz, Elizabeth A. (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
Sutcliffe, Siobhan (författare)
Alvin J. Siteman Cancer Center and Department of Surgery, Washington University School of Medicine, St. Louis, USA
Fall, Katja, 1971- (författare)
Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm
Kurth, Tobias (författare)
Department of Epidemiology, Harvard School of Public Health, Boston, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston; Institut National de la Santé et de la Recherche Médicale, Unit 708 Neuroepidemiology and Pierre et Marie Curie University, Paris, France
Ma, Jing (författare)
Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA
Stampfer, Meir J. (författare)
Department of Nutrition, School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA
Mucci, Lorelei A. (författare)
Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA
Platz, EA (författare)
Fall, K (författare)
Karolinska Institutet
Kurth, T (författare)
Mundodi, V (författare)
Judson, G (författare)
Sutcliffe, S (författare)
Mucci, LA (författare)
Stampfer, MJ (författare)
Ma, J (författare)
Alderete, JF (författare)
Giovannucci, EL (författare)
Kucknoor, AS (författare)
Stark, JR (författare)
visa färre...
 (creator_code:org_t)
Cary, USA : Oxford University Press, 2009
2009
Engelska.
Ingår i: Journal of the National Cancer Institute. - Cary, USA : Oxford University Press. - 0027-8874 .- 1460-2105. ; 101:20, s. 1406-11
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: A recent nested case-control study found that the presence of antibodies against Trichomonas vaginalis, a common nonviral sexually transmitted infection, was positively associated with subsequent incidence of prostate cancer. We confirmed these findings in an independent population and related serostatus for antibodies against T vaginalis to prostate cancer incidence and mortality.Methods: We conducted a case-control study nested within the Physicians' Health Study that included 673 case subjects with prostate cancer and 673 individually matched control subjects who had available plasma samples. Plasma from blood samples collected at baseline was assayed for antibodies against T vaginalis with an enzyme-linked immunosorbent assay. We used conditional logistic regression to estimate the odds ratios (ORs) of incident prostate cancer, extraprostatic prostate cancer, and cancer that would ultimately progress to bony metastases or prostate cancer-specific death.Results: Although not statistically significant, the magnitude of the association between T vaginalis-seropositive status and overall prostate cancer risk (OR = 1.23, 95% confidence interval [CI] = 0.94 to 1.61) was similar to that reported previously. Furthermore, a seropositive status was associated with statistically significantly increased risks of extraprostatic prostate cancer (OR = 2.17, 95% CI = 1.08 to 4.37) and of cancer that would ultimately progress to bony metastases or prostate cancer-specific death (OR = 2.69, 95% CI = 1.37 to 5.28).Conclusions: This large prospective case-control study obtained further support for an association between a seropositive status for antibodies against T vaginalis and the risk of prostate cancer, with statistically significant associations identified for the risk of extraprostatic prostate cancer and for clinically relevant, potentially lethal prostate cancer.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy