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Sökning: onr:"swepub:oai:DiVA.org:oru-41456" > Prospective study o...

  • Stark, Jennifer R.Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA (författare)

Prospective study of Trichomonas vaginalis infection and prostate cancer incidence and mortality : Physicians' Health Study

  • Artikel/kapitelEngelska2009

Förlag, utgivningsår, omfång ...

  • Cary, USA :Oxford University Press,2009
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-41456
  • urn:nbn:se:oru:diva-41456urn
  • https://doi.org/10.1093/jnci/djp306DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119525741URI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

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  • gratis
  • Background: A recent nested case-control study found that the presence of antibodies against Trichomonas vaginalis, a common nonviral sexually transmitted infection, was positively associated with subsequent incidence of prostate cancer. We confirmed these findings in an independent population and related serostatus for antibodies against T vaginalis to prostate cancer incidence and mortality.Methods: We conducted a case-control study nested within the Physicians' Health Study that included 673 case subjects with prostate cancer and 673 individually matched control subjects who had available plasma samples. Plasma from blood samples collected at baseline was assayed for antibodies against T vaginalis with an enzyme-linked immunosorbent assay. We used conditional logistic regression to estimate the odds ratios (ORs) of incident prostate cancer, extraprostatic prostate cancer, and cancer that would ultimately progress to bony metastases or prostate cancer-specific death.Results: Although not statistically significant, the magnitude of the association between T vaginalis-seropositive status and overall prostate cancer risk (OR = 1.23, 95% confidence interval [CI] = 0.94 to 1.61) was similar to that reported previously. Furthermore, a seropositive status was associated with statistically significantly increased risks of extraprostatic prostate cancer (OR = 2.17, 95% CI = 1.08 to 4.37) and of cancer that would ultimately progress to bony metastases or prostate cancer-specific death (OR = 2.69, 95% CI = 1.37 to 5.28).Conclusions: This large prospective case-control study obtained further support for an association between a seropositive status for antibodies against T vaginalis and the risk of prostate cancer, with statistically significant associations identified for the risk of extraprostatic prostate cancer and for clinically relevant, potentially lethal prostate cancer.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Judson, GregoryDepartment of Epidemiology, Harvard School of Public Health, Boston, USA (författare)
  • Alderete, John F.School of Molecular Biosciences, Washington State University, Pullman, USA (författare)
  • Mundodi, VasanthakrishnaMolecular Biosciences, Washington State University, Pullman, USA (författare)
  • Kucknoor, Ashwini S.Molecular Biosciences, Washington State University, Pullman, USA (författare)
  • Giovannucci, Edward L.Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Nutrition, School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA (författare)
  • Platz, Elizabeth A.Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA (författare)
  • Sutcliffe, SiobhanAlvin J. Siteman Cancer Center and Department of Surgery, Washington University School of Medicine, St. Louis, USA (författare)
  • Fall, Katja,1971-Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm(Swepub:oru)kafl (författare)
  • Kurth, TobiasDepartment of Epidemiology, Harvard School of Public Health, Boston, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston; Institut National de la Santé et de la Recherche Médicale, Unit 708 Neuroepidemiology and Pierre et Marie Curie University, Paris, France (författare)
  • Ma, JingChanning Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA (författare)
  • Stampfer, Meir J.Department of Nutrition, School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA (författare)
  • Mucci, Lorelei A.Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA (författare)
  • Mucci, LA (författare)
  • Judson, G (författare)
  • Platz, EA (författare)
  • Alderete, JF (författare)
  • Stark, JR (författare)
  • Fall, KKarolinska Institutet(Swepub:ki)e3b6178640f092c2ab1b8e15e39e790c (författare)
  • Giovannucci, EL (författare)
  • Mundodi, V (författare)
  • Stampfer, MJ (författare)
  • Kurth, T (författare)
  • Kucknoor, AS (författare)
  • Ma, J (författare)
  • Sutcliffe, S (författare)
  • Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USADepartment of Epidemiology, Harvard School of Public Health, Boston, USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of the National Cancer InstituteCary, USA : Oxford University Press101:20, s. 1406-110027-88741460-2105

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