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Sökning: onr:"swepub:oai:DiVA.org:oru-44593" > Aspirin and risk fo...

Aspirin and risk for gastric cancer : a population-based case-control study in Sweden

Akre [Fall], Katja, 1971- (författare)
Department of Medical Epidemiology, Karolinska Institutet, Stockholm
Ekström, A. M. (författare)
Department of Medical Epidemiology, Karolinska Institutet, Stockholm
Signorello, L B (författare)
2International Epidemiology Institute, Rockville, USA
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Hansson, L.-E. (författare)
Mora Hospital, Mora
Nyrén, O. (författare)
Department of Medical Epidemiology, Karolinska Institutet, Stockholm
Akre, K (författare)
Karolinska Institutet
Hansson, LE (författare)
Ekstrom, AM (författare)
Karolinska Institutet
Nyren, O (författare)
Karolinska Institutet
Signorello, LB (författare)
visa färre...
Edinburgh, United Kingdom : Churchill Livingstone, 2001
Ingår i: British Journal of Cancer. - Edinburgh, United Kingdom : Churchill Livingstone. - 0007-0920 .- 1532-1827. ; 84:7, s. 965-8
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
  • While aspirin and other non-steroid anti-inflammatory drugs (NSAIDs) are associated with gastric mucosal damage, they might reduce the risk for gastric cancer. In a population-based case-control study in 5 Swedish counties, we interviewed 567 incident cases of gastric cancer and 1165 controls about their use of pain relievers. The cases were uniformly classified to subsite (cardia/non-cardia) and histological type and information collected on other known risk factors for gastric cancer. Helicobacter pylori serology was tested in a subset of 542 individuals. Users of aspirin had a moderately reduced risk of gastric cancer compared to never users; odds ratio (OR) adjusted for age, gender and socioeconomic status was 0.7 (95% CI = 0.6-1.0). Gastric cancer risk fell with increasing frequency of aspirin use (P for trend = 0.02). The risk reduction was apparent for both cardia and non-cardia tumours but was uncertain for the diffuse histologic type. No clear association was observed between gastric cancer risk and non-aspirin NSAIDs or other studied pain relievers. Our finding lends support to the hypothesis that use of aspirin reduces the risk for gastric cancer.


MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)


Gastric cancer
elicobacter pylori

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