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Sökning: onr:"swepub:oai:DiVA.org:oru-44822" > Adolescent body mas...

  • Kantor, Elizabeth D.Department of Epidemiology, Harvard School of Public Health, Boston, USA (författare)

Adolescent body mass index and erythrocyte sedimentation rate in relation to colorectal cancer risk

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • London, United Kingdom :BMJ Publishing Group,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-44822
  • urn:nbn:se:oru:diva-44822urn
  • https://doi.org/10.1136/gutjnl-2014-309007DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133934644URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:National Cancer Institute T32 CA 009001Harvard School of Public HealthÖrebro University Strategic FundingUK Economic and Social Research Council (ESRC) RES-596-28-0001  ES/JO19119/1
  • gratis
  • Objective: Adult obesity and inflammation have been associated with risk of colorectal cancer (CRC); however, less is known about how adolescent body mass index (BMI) and inflammation, as measured by erythrocyte sedimentation rate (ESR), relate to CRC risk. We sought to evaluate these associations in a cohort of 239 658 Swedish men who underwent compulsory military enlistment examinations in late adolescence (ages 16-20 years).Design: At the time of the conscription assessment (1969-1976), height and weight were measured and ESR was assayed. By linkage to the national cancer registry, these conscripts were followed for CRC through 1 January 2010. Over an average of 35 years of follow-up, 885 cases of CRC occurred, including 501 colon cancers and 384 rectal cancers. Cox regression was used to estimate adjusted HRs and corresponding 95% CIs.Results: Compared with normal weight (BMI 18.5 to <25 kg/m(2)) in late adolescence, upper overweight (BMI 27.5 to <30 kg/m(2)) was associated with a 2.08-fold higher risk of CRC (95% CI 1.40 to 3.07) and obesity (BMI 30+ kg/m(2)) was associated with a 2.38-fold higher risk of CRC (95% CI 1.51 to 3.76) (p-trend: <0.001). Male adolescents with ESR (15+ mm/h) had a 63% higher risk of CRC (HR 1.63; 95% CI 1.08 to 2.45) than those with low ESR (<10 mm/h) (p-trend: 0.006). Associations did not significantly differ by anatomic site.Conclusions: Late-adolescent BMI and inflammation, as measured by ESR, may be independently associated with future CRC risk. Further research is needed to better understand how early-life exposures relate to CRC.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Udumyan, Ruzan,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics(Swepub:oru)run (författare)
  • Signorello, Lisa B.Department of Epidemiology, Harvard School of Public Health, Boston, USA (författare)
  • Giovannucci, Edward L.Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Nutrition, Harvard School of Public Health, Boston, USA; Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, USA (författare)
  • Montgomery, Scott,1961-Örebro universitet,Institutionen för medicinska vetenskaper,Research Department of Epidemiology and Public Health, University College London, London, United Kingdom; Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics(Swepub:oru)smy (författare)
  • Fall, Katja,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Epidemiology, Harvard School of Public Health, Boston, USA; Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics(Swepub:oru)kafl (författare)
  • Fall, K (författare)
  • Kantor, ED (författare)
  • Signorello, LB (författare)
  • Udumyan, R (författare)
  • Montgomery, SKarolinska Institutet (författare)
  • Giovannucci, EL (författare)
  • Department of Epidemiology, Harvard School of Public Health, Boston, USAInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:GutLondon, United Kingdom : BMJ Publishing Group65:8, s. 1289-12950017-57491468-3288

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  • Gut (Sök värdpublikationen i LIBRIS)

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