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Sökning: onr:"swepub:oai:DiVA.org:oru-48947" > Prognostic signific...

Prognostic significance and molecular features of colorectal mucinous adenocarcinomas : A strobe-compliant study

Wang, Mo-Jin (författare)
Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Sichuan University, Peoples R China; Sichuan University, Peoples R China,Department of Gastrointestinal Surgery, Institute of Digestive Surgery and State key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China; Department of Oncology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
Ping, Jie (författare)
Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Department of Oncology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
Li, Yuan (författare)
Department of Paediatric Surgery, Institute of Digestive Surgery and State key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China,Sichuan University, Peoples R China
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Holmqvist, Annica (författare)
Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Department of Oncology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
Adell, Gunnar (författare)
Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Department of Oncology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
Arbman, Gunnar (författare)
Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken ViN,Department of Oncology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
Zhang, Hong, 1957- (författare)
Örebro universitet,Institutionen för läkarutbildning,University of Örebro, Sweden
Zhou, Zong-Guang (författare)
Department of Gastrointestinal Surgery, Institute of Digestive Surgery and State key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China,Sichuan University, Peoples R China;
Sun, Xiao-Feng (författare)
Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Sichuan University, Peoples R China,Department of Gastrointestinal Surgery, Institute of Digestive Surgery and State key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China; Department of Oncology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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 (creator_code:org_t)
Lippincott Williams & Wilkins, 2015
2015
Engelska.
Ingår i: ; 94:51
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Mucinous adenocarcinoma (MC) is a special histology subtype of colorectal adenocarcinoma. The survival of MC is controversial and the prognostic biomarkers of MC remain unclear. To analyze prognostic significance and molecular features of colorectal MC. This study included 755,682 and 1001 colorectal cancer (CRC) patients from Surveillance, Epidemiology, and End Results program (SEER, 1973 2011), and Linkoping Cancer (LC, 1972-2009) databases. We investigated independently the clinicopathological characteristics, survival, and variety of molecular features from these 2 databases. MC was found in 9.3% and 9.8% patients in SEER and LC, respectively. MC was more frequently localized in the right colon compared with nonmucinous adenocarcinoma (NMC) in both SEER (57.7% vs 37.2%, P < 0.001) and LC (46.9% vs 27.7%, P < 0.001). Colorectal MC patients had significantly worse cancer-specific survival (CSS) than NMC patients (SEER, P < 0.001; LC, P = 0.026), prominently in stage III (SEER, P < 0.001; P=0.023). The multivariate survival analysis showed that MC was independently related to poor prognosis in rectal cancer patients (SEER, hazard ratios [HR], 1.076; 95% confidence intervals [CI], 1.057-1.096; P < 0.001). In LC, the integrated analysis of genetic and epigenetic features showed that that strong expression of PINCH (HR, 3.954; 95% CI, 1.493-10.47; P = 0.013) and weak expression of RAD50 (HR 0.348, 95% CT, 0.106-1.192; P=0.026) were significantly associated with poor CSS of colorectal MC patients. In conclusion, the colorectal MC patients had significantly worse CSS than NMC patients, prominently in stage III. MC was an independent prognostic factor associated with worse survival in rectal cancer patients. The PINCH and RAD50 were prognostic biomarkers for colorectal MC patients.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- General Practice (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Allmänmedicin (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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Family Medicine
Allmänmedicin

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