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Sökning: onr:"swepub:oai:DiVA.org:oru-48979" > Acetaminophen, aspi...

Acetaminophen, aspirin, and chronic renal failure

Fored, C. M. (författare)
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden; Department of Renal Medicine, Huddinge University Hospital, Huddinge, Sweden
Ejerblad, E. (författare)
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
Lindblad, Per, 1953- (författare)
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
visa fler...
Fryzek, J. P. (författare)
International Epidemiology Institute, Rockville, MD, United States; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States
Dickman, P. W. (författare)
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
Signorello, L. B. (författare)
International Epidemiology Institute, Rockville, MD, United States; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States
Lipworth, L. (författare)
International Epidemiology Institute, Rockville, MD, United States; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States
Elinder, C. G. (författare)
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden; Department of Renal Medicine, Huddinge University Hospital, Huddinge, Sweden
Blot, W. J. (författare)
International Epidemiology Institute, Rockville, MD, United States
McLaughlin, J. K. (författare)
International Epidemiology Institute, Rockville, MD, United States; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States
Zack, M. M. (författare)
National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, United States
Nyren, O. (författare)
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
McLaughlin, J K (författare)
Zack, M M (författare)
Nyren, O (författare)
Karolinska Institutet
Dickman, P W (författare)
Signorello, L B (författare)
Lipworth, L (författare)
Blot, W J (författare)
Lindblad, P (författare)
Elinder, C G (författare)
Fryzek, J P (författare)
Fored, C M (författare)
Ejerblad, E (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper,Verksamhetsområde hematologi,Blodsjukdomar
Blot, WJ (författare)
Dickman, PW (författare)
Karolinska Institutet
Signorello, LB (författare)
Fryzek, JP (författare)
Fored, CM (författare)
Karolinska Institutet
Elinder, C (författare)
Karolinska Institutet
McLaughlin, JK (författare)
Zack, MM (författare)
visa färre...
 (creator_code:org_t)
Waltham, USA : Massachusetts Medical Society, 2001
2001
Engelska.
Ingår i: New England Journal of Medicine. - Waltham, USA : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. - 0028-4793 (Print) 0028-4793 (Linking) ; 345:25, s. 1801-1808
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Several epidemiologic studies have demonstrated an association between heavy consumption of nonnarcotic analgesics and the occurrence of chronic renal failure, but it is unclear which is the cause and which is the effect.Methods: In a nationwide, population-based, case-control study of early-stage chronic renal failure in Sweden, face-to-face interviews were conducted with 926 patients with newly diagnosed renal failure and 998 control subjects, of whom 918 and 980, respectively, had complete data. We used logistic-regression models to estimate the relative risks of disease-specific types of chronic renal failure associated with the use of various analgesics.Results: Aspirin and acetaminophen were used regularly by 37 percent and 25 percent, respectively, of the patients with renal failure and by 19 percent and 12 percent, respectively, of the controls. Regular use of either drug in the absence of the other was associated with an increase by a factor of 2.5 in the risk of chronic renal failure from any cause. The relative risks rose with increasing cumulative lifetime doses, rose more consistently with acetaminophen use than with aspirin use, and were increased for most disease-specific types of chronic renal failure. When we disregarded the recent use of analgesics, which could have occurred in response to antecedents of renal disease, the associations were only slightly attenuated.Conclusions: Our results are consistent with the existence of exacerbating effects of acetaminophen and aspirin on chronic renal failure. However, we cannot rule out the possibility of bias due to the triggering of analgesic consumption by predisposing conditions.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Acetaminophen/*adverse effects
Analgesics
Non-Narcotic/*adverse effects
Anti-Inflammatory Agents
Non-Steroidal/adverse effects
Aspirin/*adverse effects
Bias (Epidemiology)
Case-Control Studies
Diabetes Complications
Dose-Response Relationship
Drug
Drug Therapy
Combination
Humans
Kidney Failure
Chronic/*chemically induced
Logistic Models
Odds Ratio
Risk Factors
Surveys and Questionnaires
Sweden
Analgesics; Non-Narcotic/*adverse effects
Anti-Inflammatory Agents; Non-Steroidal/adverse effects
Dose-Response Relationship; Drug
Drug Therapy; Combination
Kidney Failure; Chronic/*chemically induced
Questionnaires
Research Support; Non-U.S. Gov't

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