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International renal-cell cancer study. V. Reproductive factors, gynecologic operations and exogenous hormones

Lindblad, Per, 1953- (författare)
Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden; Department of Urology, Sundsvall Hospital, Sundsvall, Sweden
Mellemgaard, A., (författare)
Danish Cancer Society, Copenhagen, Denmark
Schlehofer, B., (författare)
Deutsches Krebsforschungszentrum, Heidelberg, Germany
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Adami, H. O., (författare)
Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States
McCredie, M., (författare)
Cancer Epidemiology Research Unit, NSW Cancer Council, Sydney, Australia
McLaughlin, J. K., (författare)
International Epidemiology Institute, Rockville, Maryland, United States
Mandel, J. S., (författare)
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States
LINDBLAD, P (författare)
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1995
Engelska.
Ingår i: International Journal of Cancer. - Hoboken, USA : John Wiley & Sons. - 0020-7136. - 0020-7136 (Print) 0020-7136 (Linking) ; 61:2, s. 192-198
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The relationships between reproductive factors, exogenous hormones and renal-cell cancer were examined in an international, multicenter, population-based, case-control study undertaken in 1989-1991. Data from 5 centers situated in Australia, Denmark, Germany, Sweden and the United States included for analysis 608 women with renal-cell cancer and 766 female controls. A significant trend in risk (p = 0.002) was associated with number of births, with an 80% excess risk for 6 or more births [RR = 1.8, 95% confidence interval (CI) = 1.1 to 2.9] compared with one birth. A decreasing risk was seen for increasing age at first birth, although this was confounded by body-mass index and number of births. A suggestive reduction of risk was also seen for increasing age at menarche. Age at menopause was unrelated to risk of renal-cell cancer. An increased risk was observed for women having had both a hysterectomy and an oophorectomy. Use of oral contraceptives in non-smoking women reduced the risk of renal-cell cancer (RR = 0.5, 95% CI = 0.4 to 0.8); this reduction increased with longer duration of use. No association was observed for estrogen replacement therapy. Our results indicate that certain hormonal and reproductive variables may be related to risk of renal-cell cancer and deserve further investigation, both epidemiologically and experimentally.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Adult
Aged
Australia/epidemiology
Carcinoma
Renal Cell/*epidemiology/etiology
Case-Control Studies
Contraceptives
Oral
Hormonal/*adverse effects
Denmark/epidemiology
Female
Genitalia
Female/*surgery
Germany/epidemiology
Humans
Hysterectomy/adverse effects
Kidney Neoplasms/*epidemiology/etiology
Middle Aged
Ovariectomy/adverse effects
Parity
Reproduction/*physiology
Risk Factors
Sweden/epidemiology
United States/epidemiology

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