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International renal-cell cancer study. VIII. Role of diuretics, other anti-hypertensive medications and hypertension

McLaughlin, J. K., (författare)
National Cancer Institute, Bethesda, Maryland, United States; International Epidemiology Institute, Rockville, Maryland, United States
Chow, W. H., (författare)
National Cancer Institute, Bethesda, Maryland, United States
Mandel, J. S., (författare)
Division of Environmental Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States
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Mellemgaard, A., (författare)
Danish Cancer Society, Copenhagen, Denmark
McCredie, M., (författare)
Cancer Epidemiology Research Unit, New South Wales Cancer Council, Kings Cross, Australia
Lindblad, Per, 1953- (författare)
Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden
Schlehofer, B., (författare)
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
Pommer, W., (författare)
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
Niwa, S., (författare)
Westat Inc., Rockville, Maryland, United States
Adami, H. O., (författare)
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
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1995
Engelska.
Ingår i: International Journal of Cancer. - New York, USA : John Wiley & Sons. - 0020-7136. - 0020-7136 (Print) 0020-7136 (Linking) ; 63:2, s. 216-221
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Risk of renal-cell cancer in relation to use of diuretics, other anti-hypertensive medications and hypertension was assessed in a multi-center, population-based, case-control study conducted in Australia, Denmark, Germany, Sweden and the United States, using a shared protocol and questionnaire. A total of 1,732 histologically confirmed cases and 2,309 controls, frequency-matched to cases by age and sex, were interviewed. The association between renal-cell cancer and the drugs was estimated by relative risks (RRs) and 95% confidence intervals (CIs). Risks were increased among users of diuretics and other anti-hypertensive medications. After adjustment for hypertension, risk for diuretics was reduced to unity, except among long-term (15+ years) users. Risk for use of non-diuretic anti-hypertensive drugs remained significantly elevated and increased further with duration of use. Overall risk was not enhanced when both classes of medications were used. Excess risk was not restricted to any specific type of diuretic or anti-hypertensive drug and no trend was observed with estimated lifetime consumption of any particular type of product. The RR for hypertension after adjustment for diuretics and other anti-hypertensive medications was 1.4 (95% CI = 1.2-1.7), although among non-users of any anti-hypertensive medications, there was little excess risk associated with a history of hypertension. Exclusion of drug use that first occurred within 5 years of cancer diagnosis or interview did not alter the associations. Our findings suggest small effects on renal-cell cancer risk associated with hypertension and use of diuretics and other anti-hypertensive medications. However, because of potential misclassifications of these highly correlated variables, it is difficult to distinguish the effect of treatment from its indication, hypertension.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Antihypertensive Agents/*adverse effects
Carcinoma
Renal Cell/*etiology
Case-Control Studies
Diuretics/*adverse effects/classification
Humans
Hypertension/*complications
Kidney Neoplasms/*etiology
Odds Ratio
Risk

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