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International renal-cell cancer study. I. Tobacco use

McLaughlin, J. K., (författare)
National Cancer Institute, Division of Cancer Etiology, Bethesda, Maryland, United States; International Epidemiology Institute, Rockville, Maryland, United States
Lindblad, Per, 1953- (författare)
Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden
Mellemgaard, A., (författare)
Danish Cancer Society, Copenhagen, Denmark
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McCredie, M., (författare)
Cancer Epidemiology Research Unit, New South Wales Cancer Council, Kings Cross, Australia
Mandel, J. S., (författare)
Division of Environmental Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States
Schlehofer, B., (författare)
Division of Epidemiology, German Cancer Research Center, Heidelberg, Germany
Pommer, W., (författare)
Humboldt Hospital, Berlin, Germany
Adami, H. O., (författare)
Danish Cancer Society, Copenhagen, Denmark
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1995
Engelska.
Ingår i: International Journal of Cancer. - New York, USA : John Wiley & Sons. - 0020-7136. - 0020-7136 (Print) 0020-7136 (Linking) ; 60:2, s. 194-198
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The relationship between renal-cell cancer (RCC) and tobacco use was investigated in an international, multicenter, population-based case-control study. Coordinated studies were conducted in Australia, Denmark, Germany, Sweden and the United States using a shared protocol and questionnaire. A total of 1,732 cases (1,050 men, 682 women) and 2,309 controls (1,429 men, 880 women) were interviewed for the study. No association was observed between risk and use of cigars, pipes or smokeless tobacco. A statistically significant association was observed for cigarette smoking, with current smokers having a 40% increase in risk [relative risk (RR) = 1.4, 95% confidence interval (CI) 1.2-1.7]. Risk increased with intensity (number of cigarettes) and duration (years smoked). Among current smokers the RR for pack-years rose from 1.1 (95% CI 0.8-1.5) for < 15.9 pack years to 2.0 (95% CI 1.6-2.7) for > 42 pack years (p for trend < 0.001). Long-term quitters (> 15 years) experienced a reduction in risk of about 15-25% relative to current smokers. Those who started smoking late (> 24 years of age) had about two-thirds the risk of those who started young (< or = 12 years of age). Overall, the findings of this pooled analysis confirm that cigarette smoking is a causal factor in the etiology of RCC.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Adult
Aged
Carcinoma
Renal Cell/*etiology
Case-Control Studies
Female
Humans
Kidney Neoplasms/*etiology
Male
Middle Aged
Risk
Smoking/*adverse effects

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