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International renal-cell cancer study. III. Role of weight, height, physical activity, and use of amphetamines

Mellemgaard, A., (författare)
Danish Cancer Society, Division of Cancer Epidemiology, Copenhagen, Denmark
Lindblad, Per, 1953- (författare)
Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden; Department of Urology, Sundsvall Hospital, Sundsvall, Sweden
Schlehofer, B., (författare)
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
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Bergström, R., (författare)
Dept. of Statistics, University of Uppsala, Uppsala, Sweden
Mandel, J. S., (författare)
Division of Environmental Health, School of Public Health, University of Minnesota, Minnesota, United States
McCredie, M., (författare)
Cancer Epidemiology Research Unit, NSW Cancer Council, Sydney, Australia
McLaughlin, J. K., (författare)
National Cancer Institute, Division of Cancer Etiology, Rockville, Maryland, United States
Niwa, S., (författare)
WESTAT Inc, Rockville, Maryland, United States
Odaka, N., (författare)
WESTAT Inc, Rockville, Maryland, United States
Pommer, W., (författare)
Humbolt Hospital, Berlin, Germany
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Ingår i: International Journal of Cancer. - New York, USA : John Wiley & Sons. - 0020-7136. - 0020-7136 (Print) 0020-7136 (Linking) ; 60:3, s. 350-354
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
  • Although numerous studies have identified obesity or high relative weight as a risk factor for renal-cell cancer in women, the degree to which this effect is present in men remains unclear. A multicenter population-based case-control study concerning incident cases of histologically verified renal-cell cancer (n = 1,732) and age- and sex-matched controls (n = 2,309) was conducted in Australia, Denmark, Germany (2 centers), Sweden and the United States. Relative weight was estimated by the body mass index, and the association between this factor and other factors, such as height, physical activity and use of amphetamines, was measured by the relative risk estimated in logistic regression models. Body mass index was found to be a risk factor among women and, to a lesser extent, among men. A 3-fold increased risk (RR = 3.6, 95% CI = 2.3-5.7) was observed for women with a relative weight in the top 5% compared with those in the lowest quartile. Rate of weight change (estimated as weight change per annum in kilograms) appeared to be an independent risk factor among women but not among men. Physical activity and height were unrelated to risk of renal-cell cancer regardless of level of BMI, while use of amphetamines was associated with an increased risk among men, although no dose or duration effect was seen. Our findings verify the link between high relative weight and risk of renal-cell cancer, particularly among women. The mechanism that underlies this association is, however, still unclear, although the rate of weight change may play a role.


MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)


Amphetamines/*adverse effects
Body Weight
Renal Cell/*etiology
Case-Control Studies
Kidney Neoplasms/*etiology
Middle Aged
Physical Fitness

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